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National Cancer Institute Thesaurus
| Preferred Name | Polymerase Chain Reaction | |
| Synonyms |
Polymerase Chain Reaction polymerase chain reaction POLYMERASE CHAIN REACTION PCR |
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| Definitions |
A method for amplifying a DNA base sequence using multiple rounds of heat denaturation of the DNA and annealing of oligonucleotide primers complementary to flanking regions in the presence of a heat-stable polymerase. This results in duplication of the targeted DNA region. Newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, so that successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17003 |
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| ALT_DEFINITION |
A method for amplifying a DNA base sequence using multiple rounds of heat denaturation of the DNA and annealing of oligonucleotide primers complementary to flanking regions in the presence of a heat-stable polymerase. This results in duplication of the targeted DNA region. Newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, so that successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample. A laboratory method used to make many copies of a specific DNA sequence.
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| code |
C17003
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174252 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157526 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186323 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174237 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177415 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179027 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118169 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C179534 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156953 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C85492 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C189083 |
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| Contributing_Source |
CDISC CPTAC CTRP GDC PCDC SeroNet
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| DEFINITION |
A method for amplifying a DNA base sequence using multiple rounds of heat denaturation of the DNA and annealing of oligonucleotide primers complementary to flanking regions in the presence of a heat-stable polymerase. This results in duplication of the targeted DNA region. Newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, so that successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence. PCR also can be used to detect the existence of the defined sequence in a DNA sample.
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| Display_Name |
Polymerase Chain Reaction
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| FULL_SYN |
Polymerase Chain Reaction polymerase chain reaction POLYMERASE CHAIN REACTION PCR
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| Is_PCDC_EWS_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Polymerase Chain Reaction
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| Legacy Concept Name |
Polymerase_Chain_Reaction
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| Maps_To |
PCR
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| Preferred_Name |
Polymerase Chain Reaction
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| prefixIRI |
Thesaurus:C17003
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| Semantic_Type |
Laboratory Procedure
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| UMLS_CUI |
C0032520
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| subClassOf |
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