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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Fibronectin | |
| Synonyms |
Fibronectin Isoform 1 Isoform 1 Fibronectin Large External Transformation-Sensitive Protein Fibronectin Cold-Insoluble Globulin Large, External, Transformation-Sensitive Protein LETS Protein Fibronectin 1 CIG FN FN1 FNZ LETS |
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| Definitions |
Fibronectin (2386 aa, ~263 kDa) is encoded by the human FN1 gene. This protein is involved in cell adhesion- and migration-dependent processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16581 |
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| code |
C16581
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 |
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| Contributing_Source |
CTRP
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| DEFINITION |
Fibronectin (2386 aa, ~263 kDa) is encoded by the human FN1 gene. This protein is involved in cell adhesion- and migration-dependent processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis.
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| DesignNote |
Fibronectin can be cleaved to form Ugl-Y1, Ugl-Y2, Ugl-Y3 and anastellin. (UniProt) Anastellin is a 76 amino acid fragment from carboxy-terminal portion of the first fibronectin type-III domain with potential antiangiogenic activity. Anastellin binds fibronectin and induces fibril formation; the resulting fibronectin polymer, superfibronectin, exhibits enhanced adhesive properties and may also inhibit angiogenesis. (UniProt)
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| Display_Name |
Fibronectin
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| FULL_SYN |
Fibronectin Isoform 1 Isoform 1 Fibronectin Large External Transformation-Sensitive Protein Fibronectin Cold-Insoluble Globulin Large, External, Transformation-Sensitive Protein LETS Protein Fibronectin 1 CIG FN FN1 FNZ LETS
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|
| label |
Fibronectin
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|
| Legacy Concept Name |
Fibronectin
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| NCI_META_CUI |
CL1379609
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|
| OMIM_Number |
135600
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| Preferred_Name |
Fibronectin
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| prefixIRI |
Thesaurus:C16581
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| Semantic_Type |
Amino Acid, Peptide, or Protein
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| Swiss_Prot |
P02751
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| subClassOf |
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