loading...| Preferred Name | Cadherin | |
| Synonyms |
Cadherin |
|
| Definitions |
The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16373 |
|
| code |
C16373 |
|
| DEFINITION |
The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets. |
|
| FULL_SYN |
Cadherin |
|
| label |
Cadherin |
|
| Legacy Concept Name |
Cadherin |
|
| Preferred_Name |
Cadherin |
|
| prefixIRI |
Thesaurus:C16373 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein |
|
| UMLS_CUI |
C0006631 |
|
| subClassOf |