loading...| Preferred Name | Biomarker | |
| Synonyms |
Signature Molecule biological marker signature molecule Molecular Marker molecular marker Biological Markers Biological Marker Biomarker Biomarkers biomarker marker |
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| Definitions |
A characteristic that can be objectively measured and serves as an indicator for normal biologic processes, pathogenic processes, state of health or disease, the risk for disease development and/or prognosis, or responsiveness to a particular therapeutic intervention. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16342 |
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| ALT_DEFINITION |
A biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. A defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Molecular, histologic, radiographic, or physiologic characteristics are types of biomarkers. A biomarker is not an assessment of how an individual feels, functions, or survives. Categories of biomarkers include: susceptibility/risk biomarker; diagnostic biomarker; monitoring biomarker; prognostic biomarker; predictive biomarker; safety biomarker; pharmacodynamic/response biomarker. [NIH-FDA BEST (Biomarkers, Endpoints, and other Tools) Resource, https://www.ncbi.nlm.nih.gov/books/NBK338448/] A characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. (From: FDA Guidance for Industry: Pharmacogenomic Data Submissions.) A measurable and quantifiable biological parameter which serves as index for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc. [Source: adapted from MESH] EXAMPLE(S): Specific enzyme concentration Specific hormone concentration Specific gene phenotype distribution in a population Presence of biological substances OTHER NAME(S): NOTE(S): A defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions. Molecular, histologic, radiographic, or physiologic characteristics are types of biomarkers. Categories of biomarkers include: susceptibility/risk biomarker; diagnostic biomarker; monitoring biomarker; prognostic biomarker; predictive biomarker; safety biomarker; pharmacodynamic/response biomarker. [NIH-FDA BEST (Biomarkers, Endpoints, and other Tools) Resource, https://www.ncbi.nlm.nih.gov/books/NBK338448/] (CDISC Glossary) |
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| CHEBI_ID |
CHEBI:59163 |
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| code |
C16342 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132298 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159501 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132310 |
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| Contributing_Source |
CDISC-GLOSS BRIDG CDISC |
|
| DEFINITION |
A characteristic that can be objectively measured and serves as an indicator for normal biologic processes, pathogenic processes, state of health or disease, the risk for disease development and/or prognosis, or responsiveness to a particular therapeutic intervention. |
|
| FULL_SYN |
Signature Molecule biological marker signature molecule Molecular Marker molecular marker Biological Markers Biological Marker Biomarker Biomarkers biomarker marker |
|
| label |
Biomarker |
|
| Legacy Concept Name |
Biomarker |
|
| Preferred_Name |
Biomarker |
|
| prefixIRI |
Thesaurus:C16342 |
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| Semantic_Type |
Functional Concept |
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| UMLS_CUI |
C0005516 |
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| subClassOf |