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National Cancer Institute Thesaurus
| Preferred Name | Idarubicin Hydrochloride | |
| Synonyms |
Idarubicin HCl Idamycin PFS IDARUBICIN HYDROCHLORIDE Idarubicin Hydrochloride Idarubicin hydrochloride IMI-30 Idamycin SC-33428 Zavedos |
|
| Definitions |
The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1587 |
|
| Accepted_Therapeutic_Use_For |
In combination therapies for acute myelogenous leukemia and pediatric acute lymphocytic leukemia.
|
|
| CAS_Registry |
57852-57-0
|
|
| Chemical_Formula |
C26H27NO9.HCl
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|
| code |
C1587
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC
|
|
| DEFINITION |
The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds
|
|
| Display_Name |
Idarubicin Hydrochloride
|
|
| FDA_UNII_Code |
5VV3MDU5IE
|
|
| FULL_SYN |
Idarubicin HCl Idamycin PFS IDARUBICIN HYDROCHLORIDE Idarubicin Hydrochloride Idarubicin hydrochloride IMI-30 Idamycin SC-33428 Zavedos
|
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Idarubicin Hydrochloride
|
|
| Legacy Concept Name |
Idarubicin_Hydrochloride
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|
| Maps_To |
Idarubicin Hydrochloride
|
|
| NCI_Drug_Dictionary_ID |
39753
|
|
| NSC Number |
256439
|
|
| PDQ_Closed_Trial_Search_ID |
39753
|
|
| PDQ_Open_Trial_Search_ID |
39753
|
|
| Preferred_Name |
Idarubicin Hydrochloride
|
|
| prefixIRI |
Thesaurus:C1587
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0939353
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|
| subClassOf |
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