Anthracyclines

Anthracycline Antineoplastic Antibiotic

anthracycline

Chemotherapy, Cancer, Anthracyclines

An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1594

A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die. Daunorubicin, doxorubicin, and epirubicin are anthracyclines.

CHEBI:49322

C1594

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

CTRP

An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.

Anthracycline Antineoplastic Antibiotic

Anthracyclines

Anthracycline Antineoplastic Antibiotic

anthracycline

Chemotherapy, Cancer, Anthracyclines

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17766

Anthracycline Antineoplastic Antibiotic

Anthracycline_Antibiotic

Anthracycline Antineoplastic Antibiotic

Thesaurus:C1594

Chemical Viewed Functionally

C0282564

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1968

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C259

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2115