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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Dexverapamil | |
| Synonyms |
Dexverapamil R Verapamil DEXVERAPAMIL R-Verapamil |
|
| Definitions |
The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1563 |
|
| CAS_Registry |
38321-02-7
|
|
| Chemical_Formula |
C27H38N2O4
|
|
| code |
C1563
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04)
|
|
| FDA_UNII_Code |
QR5PYD126V
|
|
| FULL_SYN |
Dexverapamil R Verapamil DEXVERAPAMIL R-Verapamil
|
|
| label |
Dexverapamil
|
|
| Legacy Concept Name |
Dexverapamil
|
|
| NCI_Drug_Dictionary_ID |
41269
|
|
| PDQ_Closed_Trial_Search_ID |
41269
|
|
| PDQ_Open_Trial_Search_ID |
41269
|
|
| Preferred_Name |
Dexverapamil
|
|
| prefixIRI |
Thesaurus:C1563
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0280858
|
|
| subClassOf |
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