loading...| Preferred Name |
Topotecan |
|
| Synonyms |
Hycamptamine Topotecan Lactone 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione TOPOTECAN Topotecan topotecan |
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| Definitions |
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1413 |
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| ALT_DEFINITION |
A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan is a type of topoisomerase inhibitor. |
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| CAS_Registry |
123948-87-8 |
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| CHEBI_ID |
CHEBI:63632 |
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| Chemical_Formula |
C23H23N3O5 |
|
| code |
C1413 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc |
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| DEFINITION |
A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. |
|
| Display_Name |
Topotecan |
|
| FDA_UNII_Code |
7M7YKX2N15 |
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| FULL_SYN |
Hycamptamine Topotecan Lactone 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione TOPOTECAN Topotecan topotecan |
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| Has_Salt_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Topotecan |
|
| Legacy Concept Name |
Topotecan |
|
| Maps_To |
Topotecan |
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| NSC Number |
641007 |
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| Preferred_Name |
Topotecan |
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| prefixIRI |
Thesaurus:C1413 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0146224 |
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| subClassOf |