loading...| Preferred Name |
Trimetrexate |
|
| Synonyms |
Trimetrexate 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]- 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine TRIMETREXATE CI-898 TMQ Trimexate |
|
| Definitions |
A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1314 |
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| CAS_Registry |
52128-35-5 |
|
| Chemical_Formula |
C19H23N5O3 |
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| code |
C1314 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04) |
|
| FDA_UNII_Code |
UPN4ITI8T4 |
|
| FULL_SYN |
Trimetrexate 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]- 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine TRIMETREXATE CI-898 TMQ Trimexate |
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| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Trimetrexate |
|
| Legacy Concept Name |
Trimetrexate |
|
| Maps_To |
Trimetrexate |
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| NSC Number |
249008 |
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| Preferred_Name |
Trimetrexate |
|
| prefixIRI |
Thesaurus:C1314 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0085176 |
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| subClassOf |