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National Cancer Institute Thesaurus
| Preferred Name | Clarithromycin | |
| Synonyms |
6-O-Methylerythromycin Clarithromycin CLARITHROMYCIN clarithromycin Abbott-56268 Biaxin |
|
| Definitions |
A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1054 |
|
| Accepted_Therapeutic_Use_For |
H. pylori infection; Various bacterial infections
|
|
| ALT_DEFINITION |
An antibiotic drug used to treat infection. It belongs to the family of drugs called macrolides.
|
|
| CAS_Registry |
81103-11-9
|
|
| CHEBI_ID |
CHEBI:3732
|
|
| Chemical_Formula |
C38H69NO13
|
|
| code |
C1054
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc
|
|
| DEFINITION |
A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04)
|
|
| Display_Name |
Clarithromycin
|
|
| FDA_UNII_Code |
H1250JIK0A
|
|
| FULL_SYN |
6-O-Methylerythromycin Clarithromycin CLARITHROMYCIN clarithromycin Abbott-56268 Biaxin
|
|
| Is_Value_For_GDC_Property | ||
| label |
Clarithromycin
|
|
| Legacy Concept Name |
Clarithromycin
|
|
| Maps_To |
Clarithromycin
|
|
| NCI_Drug_Dictionary_ID |
42308
|
|
| NSC Number |
643733
|
|
| PDQ_Closed_Trial_Search_ID |
42308
|
|
| PDQ_Open_Trial_Search_ID |
42308
|
|
| Preferred_Name |
Clarithromycin
|
|
| prefixIRI |
Thesaurus:C1054
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
|
|
| UMLS_CUI |
C0055856
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|
| subClassOf |
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