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National Cancer Institute Thesaurus
| Preferred Name | Interferon Gamma-1b | |
| Synonyms |
IFN-gamma 1b N(sup 2)-L-Methionyl-1-139-interferon gamma (Human Lymphocyte Protein Moiety Reduced) Interferon gamma-1b, Recombinant Recombinant Interferon Gamma-1b gamma Interferon 1B Interferon gamma-1b Interferon Gamma-1b INTERFERON GAMMA-1B N(Sup 2)-L-Methionyl-1-139-Interferon G Actimmune IFN-g-1b IFNg-1b |
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| Definitions |
A recombinant form of the endogenous cytokine human interferon (IFN) gamma-1b, with immunomodulating activity. Upon administration, IFN gamma-1b targets, binds to, and activates the cell-surface IFN-gamma receptor, stimulating antibody dependent cellular cytotoxicity (ADCC), activating natural killer (NK) cells, and enhancing the oxidative metabolism of macrophages. IFN-gamma plays important roles in the innate and adaptive immune responses. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C100089 |
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| CAS_Registry |
98059-61-1
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|
| code |
C100089
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc
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|
| DEFINITION |
A recombinant form of the endogenous cytokine human interferon (IFN) gamma-1b, with immunomodulating activity. Upon administration, IFN gamma-1b targets, binds to, and activates the cell-surface IFN-gamma receptor, stimulating antibody dependent cellular cytotoxicity (ADCC), activating natural killer (NK) cells, and enhancing the oxidative metabolism of macrophages. IFN-gamma plays important roles in the innate and adaptive immune responses.
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|
| Display_Name |
Interferon Gamma-1b
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|
| FDA_UNII_Code |
21K6M2I7AG
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|
| FULL_SYN |
IFN-gamma 1b N(sup 2)-L-Methionyl-1-139-interferon gamma (Human Lymphocyte Protein Moiety Reduced) Interferon gamma-1b, Recombinant Recombinant Interferon Gamma-1b gamma Interferon 1B Interferon gamma-1b Interferon Gamma-1b INTERFERON GAMMA-1B N(Sup 2)-L-Methionyl-1-139-Interferon G Actimmune IFN-g-1b IFNg-1b
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|
| Is_Value_For_GDC_Property | ||
| label |
Interferon Gamma-1b
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|
| Maps_To |
Interferon Gamma-1b
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|
| NCI_Drug_Dictionary_ID |
784898
|
|
| PDQ_Closed_Trial_Search_ID |
784898
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|
| PDQ_Open_Trial_Search_ID |
784898
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|
| Preferred_Name |
Interferon Gamma-1b
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|
| prefixIRI |
Thesaurus:C100089
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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|
| UMLS_CUI |
C1579322
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| subClassOf |
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