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National Cancer Institute Thesaurus
| Preferred Name | Recombinant Interferon Gamma | |
| Synonyms |
INTERFERON GAMMA Interferon Gamma (BIO) Gamma Interferon-SCH Interferon Gamma Gamma-Interferon Interferon, Gamma Gamma Interferon (GEN) Recombinant Interferon Gamma Ginterferon IFN-g |
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C583 |
|
| Accepted_Therapeutic_Use_For |
Chronic granulomatous disease; Osteopetrosis
|
|
| CAS_Registry |
82115-62-6
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|
| code |
C583
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC
|
|
| DEFINITION |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
|
|
| Display_Name |
Recombinant Interferon Gamma
|
|
| FDA_UNII_Code |
P050J5FWC5
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|
| FULL_SYN |
INTERFERON GAMMA Interferon Gamma (BIO) Gamma Interferon-SCH Interferon Gamma Gamma-Interferon Interferon, Gamma Gamma Interferon (GEN) Recombinant Interferon Gamma Ginterferon IFN-g
|
|
| Is_Value_For_GDC_Property | ||
| label |
Recombinant Interferon Gamma
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|
| Legacy Concept Name |
Therapeutic_Interferon_Gamma
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|
| Maps_To |
Recombinant Interferon Gamma
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|
| NCI_Drug_Dictionary_ID |
40469
|
|
| NSC Number |
600662 635256
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|
| PDQ_Closed_Trial_Search_ID |
40469
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|
| PDQ_Open_Trial_Search_ID |
40469
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|
| Preferred_Name |
Recombinant Interferon Gamma
|
|
| prefixIRI |
Thesaurus:C583
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance
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|
| UMLS_CUI |
C3539881
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|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://purl.bioontology.org/ontology/PDQ/CDR0000040469 | PDQ | LOOM |
| http://purl.bioontology.org/ontology/PDQ/CDR0000040469 | PDQ | LOOM |
| http://purl.obolibrary.org/obo/NCIT_C583 | BERO | LOOM |