National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Recombinant Interferon Gamma
Synonyms

INTERFERON GAMMA

Interferon Gamma (BIO)

Gamma Interferon-SCH

Interferon Gamma

Gamma-Interferon

Interferon, Gamma

Gamma Interferon (GEN)

Recombinant Interferon Gamma

Ginterferon

IFN-g
Definitions

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C583
Accepted_Therapeutic_Use_For

Chronic granulomatous disease; Osteopetrosis
CAS_Registry

82115-62-6
code

C583
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537
Contributing_Source

CTRP

FDA

GDC
DEFINITION

A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
Display_Name

Recombinant Interferon Gamma
FDA_UNII_Code

P050J5FWC5
FULL_SYN

INTERFERON GAMMA

Interferon Gamma (BIO)

Gamma Interferon-SCH

Interferon Gamma

Gamma-Interferon

Interferon, Gamma

Gamma Interferon (GEN)

Recombinant Interferon Gamma

Ginterferon

IFN-g
Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909
label

Recombinant Interferon Gamma
Legacy Concept Name

Therapeutic_Interferon_Gamma
Maps_To

Recombinant Interferon Gamma
NCI_Drug_Dictionary_ID

40469
NSC Number

600662

635256
PDQ_Closed_Trial_Search_ID

40469
PDQ_Open_Trial_Search_ID

40469
Preferred_Name

Recombinant Interferon Gamma
prefixIRI

Thesaurus:C583
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C3539881
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C584
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