loading...| Preferred Name | glioblastoma | |
| Synonyms |
grade IV adult astrocytic tumor grade IV adult astrocytic tumour gliosarcoma (histologic variant) giant cell glioblastoma (histologic variant) GBM (glioblastoma) glioblastoma multiforme (disease) GBM grade IV astrocytic tumour grade IV astrocytic tumor spongioblastoma multiforme glioblastoma primary glioblastoma multiforme glioblastoma (disease) glioblastoma multiforme WHO grade IV glioma grade IV astrocytoma grade IV astrocytic neoplasm |
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| Definitions |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) |
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| ID |
http://purl.obolibrary.org/obo/MONDO_0018177 |
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| database_cross_reference |
UMLS:C0017636 NORD:1187 NANDO:2200087 MEDGEN:42228 SCTID:393563007 DOID:3068 Orphanet:360 ONCOTREE:GB HP:0012174 ICDO:9440/3 ONCOTREE:GBM MedDRA:10018336 EFO:0000519 NCIT:C3058 GARD:2491 MedDRA:10018337 HP:0100843 MESH:D005909 |
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| definition |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) |
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| has_exact_synonym |
GBM (glioblastoma) glioblastoma multiforme (disease) GBM grade IV astrocytic tumour grade IV astrocytic tumor spongioblastoma multiforme glioblastoma primary glioblastoma multiforme glioblastoma (disease) glioblastoma multiforme WHO grade IV glioma grade IV astrocytoma grade IV astrocytic neoplasm |
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| has_narrow_synonym |
grade IV adult astrocytic tumor grade IV adult astrocytic tumour |
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| has_related_synonym |
gliosarcoma (histologic variant) giant cell glioblastoma (histologic variant) |
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| IAO_0000233 | ||
| IAO_0000589 |
glioblastoma (disease) |
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| id |
MONDO:0018177 |
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| in_subset |
http://purl.obolibrary.org/obo/mondo/mondo-simple#otar http://purl.obolibrary.org/obo/mondo/mondo-simple#orphanet_rare http://purl.obolibrary.org/obo/mondo/mondo-simple#rare http://purl.obolibrary.org/obo/mondo/mondo-simple#ordo_disorder |
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| label |
glioblastoma |
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| notation |
MONDO:0018177 |
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| prefLabel |
glioblastoma |
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| skos_closeMatch | ||
| skos_exactMatch |
http://linkedlifedata.com/resource/umls/id/C0017636 http://purl.obolibrary.org/obo/Orphanet_360 http://purl.obolibrary.org/obo/EFO_0000519 http://identifiers.org/snomedct/393563007 http://identifiers.org/mesh/D005909 http://purl.obolibrary.org/obo/DOID_3068 |
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| treeView | ||
| subClassOf |