loading...| Preferred Name |
hepatocellular carcinoma |
|
| Synonyms |
hepatocellular carcinoma, childhood type, somatic liver cell carcinoma carcinoma of the liver cells primary carcinoma of liver cells liver cell cancer (hepatocellular carcinoma) hepatocellular cancer, somatic primary carcinoma of the liver cells cancer, hepatocellular carcinoma, hepatocellular, malignant carcinoma of liver cells hepatocellular carcinoma, somatic hepatocellular adenocarcinoma hepatocellular carcinoma hepatoblastoma, somatic hepatocellular cancer carcinoma of liver liver carcinoma HCC hepatoma hepatoblastoma liver cancer liver and intrahepatic bile duct carcinoma hepatoblastoma caused by somatic mutation adult primary hepatocellular carcinoma adult hepatoma |
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| Definitions |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
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| ID |
http://purl.obolibrary.org/obo/MONDO_0007256 |
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| closeMatch | ||
| database_cross_reference |
MESH:D006528 OMIM:114550 icd11.foundation:1294035808 DOID:684 NCIT:C3099 Orphanet:88673 EFO:0000182 NORD:1907 DOID:686 GARD:16773 MedDRA:10049010 ONCOTREE:HCC ICDO:8170/3 |
|
| definition |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
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| disease arises from structure | ||
| exactMatch |
http://purl.obolibrary.org/obo/NCIT_C3099 http://identifiers.org/mesh/D006528 http://purl.obolibrary.org/obo/Orphanet_88673 http://purl.obolibrary.org/obo/DOID_686 |
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| has_exact_synonym |
hepatocellular carcinoma, childhood type, somatic liver cell carcinoma carcinoma of the liver cells primary carcinoma of liver cells liver cell cancer (hepatocellular carcinoma) hepatocellular cancer, somatic primary carcinoma of the liver cells cancer, hepatocellular carcinoma, hepatocellular, malignant carcinoma of liver cells hepatocellular carcinoma, somatic hepatocellular adenocarcinoma hepatocellular carcinoma hepatoblastoma, somatic hepatocellular cancer carcinoma of liver liver carcinoma HCC hepatoma |
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| has_narrow_synonym |
adult primary hepatocellular carcinoma adult hepatoma |
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| has_related_synonym |
hepatoblastoma liver cancer liver and intrahepatic bile duct carcinoma hepatoblastoma caused by somatic mutation |
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| IAO_0000233 | ||
| id |
MONDO:0007256 |
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| in_subset |
http://purl.obolibrary.org/obo/mondo#rare http://purl.obolibrary.org/obo/mondo#nord_rare http://purl.obolibrary.org/obo/mondo#otar http://purl.obolibrary.org/obo/mondo#gard_rare http://purl.obolibrary.org/obo/mondo#ordo_group_of_disorders |
|
| label |
hepatocellular carcinoma |
|
| notation |
MONDO:0007256 |
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| prefLabel |
hepatocellular carcinoma |
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| treeView |
http://purl.obolibrary.org/obo/MONDO_0004993 |
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| subClassOf |
http://purl.obolibrary.org/obo/MONDO_0004993 |