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Myocardial Infarction Ontology
| Preferred Name | warfarin | |
| Synonyms |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin compound 42 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin athrombin-K 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone co-Rax rodex |
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| Definitions |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. [url:http://purl.obolibrary.org/obo/NCIT_C945] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02640 |
|
| definition |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. [url:http://purl.obolibrary.org/obo/NCIT_C945]
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| label |
warfarin
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| MIO_ID |
MIO:02640
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| prefLabel |
warfarin
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| reference |
UMLS:C0043031 NCIT:C945
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| synonyms |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin compound 42 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin athrombin-K 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone co-Rax rodex
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| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02149 |
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