loading...| Preferred Name |
warfarin |
|
| Synonyms |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin compound 42 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin athrombin-K 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone co-Rax rodex |
|
| Definitions |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. [url:http://purl.obolibrary.org/obo/NCIT_C945] |
|
| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02640 |
|
| definition |
A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. [url:http://purl.obolibrary.org/obo/NCIT_C945] |
|
| label |
warfarin |
|
| MIO_ID |
MIO:02640 |
|
| prefLabel |
warfarin |
|
| reference |
UMLS:C0043031 NCIT:C945 |
|
| synonyms |
3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin compound 42 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin athrombin-K 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin WARF compound 42 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone co-Rax rodex |
|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02149 |