loading...| Preferred Name | methotrexate | |
| Synonyms |
methotrexate methotrexate methylaminopterin alpha-methopterin farmitrexat methotrexate LPF methotrexatum metotrexato ledertrexate 4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid methoblastin N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid medsatrexate amethopterin 4-amino-10-methylfolic acid CL 14377 CL-14377 MTX WR-19039 abitrexate brimexate emtexate emthexat emthexate fauldexato folex folex PFS lantarel lumexon maxtrex metex metrotex mexate mexate-AQ novatrex rheumatrex texate tremetex trexeron trixilem |
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| Definitions |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. [url:http://purl.obolibrary.org/obo/NCIT_C642] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02537 |
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| definition |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. [url:http://purl.obolibrary.org/obo/NCIT_C642] |
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| label |
methotrexate |
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| MIO_ID |
MIO:02537 |
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| prefLabel |
methotrexate |
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| reference |
NCIT:C642 |
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| synonyms |
methotrexate methotrexate methylaminopterin alpha-methopterin farmitrexat methotrexate LPF methotrexatum metotrexato ledertrexate 4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid methoblastin N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid medsatrexate amethopterin 4-amino-10-methylfolic acid CL 14377 CL-14377 MTX WR-19039 abitrexate brimexate emtexate emthexat emthexate fauldexato folex folex PFS lantarel lumexon maxtrex metex metrotex mexate mexate-AQ novatrex rheumatrex texate tremetex trexeron trixilem |
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| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01924 |