loading...| Preferred Name |
rosuvastatin |
|
| Synonyms |
rosuvastatin |
|
| Definitions |
A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades. [url:http://purl.obolibrary.org/obo/NCIT_C66523] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02127 |
|
| definition |
A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades. [url:http://purl.obolibrary.org/obo/NCIT_C66523] |
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| label |
rosuvastatin |
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| MIO_ID |
MIO:02127 |
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| prefLabel |
rosuvastatin |
|
| reference |
NCIT:C66523 |
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| synonyms |
rosuvastatin |
|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01067 |