Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Multiple System Atrophy
Synonyms	Atrophy, Multisystemic Atrophies, Multisystem Multisystem Atrophy Multisystemic Atrophies Multisystemic Atrophy Atrophies, Multisystemic Atrophy, Multiple System Multiple System Atrophy Syndrome Multiple System Atrophies Multisystem Atrophies Atrophy, Multisystem
Definitions	A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
ID	http://purl.bioontology.org/ontology/MESH/D019578
altLabel	Atrophy, Multisystemic Atrophies, Multisystem Multisystem Atrophy Multisystemic Atrophies Multisystemic Atrophy Atrophies, Multisystemic Atrophy, Multiple System Multiple System Atrophy Syndrome Multiple System Atrophies Multisystem Atrophies Atrophy, Multisystem
AN	a specific neurodegenerative syndrome complex; not for atrophy in other systems
AQL	BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI
cui	C0393571
DC	1
definition	A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
DX	19980101
FX	D009849 D012791
HN	1998
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000178 http://purl.bioontology.org/ontology/MESH/Q000175 http://purl.bioontology.org/ontology/MESH/Q000628 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000139 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000517 http://purl.bioontology.org/ontology/MESH/Q000662 http://purl.bioontology.org/ontology/MESH/Q000469 http://purl.bioontology.org/ontology/MESH/Q000151 http://purl.bioontology.org/ontology/MESH/Q000150 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000196 http://purl.bioontology.org/ontology/MESH/Q000473 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000451 http://purl.bioontology.org/ontology/MESH/Q000453 http://purl.bioontology.org/ontology/MESH/Q000534 http://purl.bioontology.org/ontology/MESH/Q000532 http://purl.bioontology.org/ontology/MESH/Q000503 http://purl.bioontology.org/ontology/MESH/Q000188 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000201 http://purl.bioontology.org/ontology/MESH/Q000209 http://purl.bioontology.org/ontology/MESH/Q000208 http://purl.bioontology.org/ontology/MESH/Q000601 http://purl.bioontology.org/ontology/MESH/Q000000981 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000523 http://purl.bioontology.org/ontology/MESH/Q000401
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D012791 http://purl.bioontology.org/ontology/MESH/D009849
Machine permutation	1998
Mapped from	http://purl.bioontology.org/ontology/MESH/C537381
MDA	19970620
MMR	20190517
MN	C10.228.140.079.612 C10.574.928.625 C10.177.575.550 C10.228.662.550
notation	D019578
prefLabel	Multiple System Atrophy
TERMUI	T364299 T364305 T058282 T364298
TH	OMIM (2013) NLM (2000) GHR (2014) NLM (1998) ORD (2010)
tui	T046
subClassOf	http://purl.bioontology.org/ontology/MESH/D009069 http://purl.bioontology.org/ontology/MESH/D054969 http://purl.bioontology.org/ontology/MESH/D000080874 http://purl.bioontology.org/ontology/MESH/D001480

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RCD/X003n	RCD	CUI
http://purl.bioontology.org/ontology/SCTSPA/230297002	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/230297002	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MDRFRE/10064060	MDRFRE	CUI
http://purl.bioontology.org/ontology/MEDDRA/10064060	MEDDRA	CUI
http://purl.bioontology.org/ontology/MSHFRE/D019578	MSHFRE	CUI
http://purl.bioontology.org/ontology/MDRGER/10064060	MDRGER	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000003942	NDFRT	CUI
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0393571	MEDLINEPLUS	CUI
http://purl.obolibrary.org/obo/DOID_4752	DOID	LOOM
http://purl.obolibrary.org/obo/MONDO_0007803	MONDO	LOOM
http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#Multiple_system_atrophy	PDON	LOOM
http://purl.obolibrary.org/obo/MONDO_0007803	DOVES	LOOM
http://purl.bioontology.org/ontology/RCD/X003n	RCD	LOOM
http://purl.bioontology.org/ontology/RCTV2/F174.00	RCTV2	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0393571	OCHV	LOOM
http://www.ebi.ac.uk/efo/EFO_1001050	CCONT	LOOM
http://www.ebi.ac.uk/efo/EFO_1001050	EFO	LOOM
http://www.limics.org/hrdo/rdfns#pat_id_8744	HRDO	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Multiple_System_Atrophy	APANEUROCLUSTER	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Multiple_System_Atrophy	APAONTO	LOOM
http://purl.org/obo/owl/DOID#DOID_4752	HUPSON	LOOM
http://purl.obolibrary.org/obo/NCIT_C84909	BERO	LOOM
http://www.case.edu/PMDO#MultipleSystemAtrophy	PMDO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.228.140.079.612	RH-MESH	LOOM
http://www.owl-ontologies.com/NPOntology.owl#DOID_4752	NATPRO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/230297002	SNOMEDCT	LOOM
http://www.orpha.net/ORDO/Orphanet_102	ORDO	LOOM
http://purl.obolibrary.org/obo/Multiple_System_Atrophy	NND_ND	LOOM
http://www.radlex.org/RID/RID5158	RADLEX	LOOM
http://purl.bioontology.org/ontology/MEDDRA/10064060	MEDDRA	LOOM
http://purl.obolibrary.org/obo/OMIT_0019602	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.177.575.550	RH-MESH	LOOM
http://nanbyodata.jp/ontology/NANDO_1200034	NANDO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.228.662.550	RH-MESH	LOOM
http://bioontology.org/projects/ontologies/birnlex#birnlex_12573	BIRNLEX	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.574.625	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D019578	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84909	NCIT	LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Multiple_System_atrophy	NIO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Multiple_System_Atrophy	CSEO	LOOM
http://purl.obolibrary.org/obo/DOID_4752	DTO	LOOM
http://purl.obolibrary.org/obo/DOID_4752	DOID	LOOM
http://purl.obolibrary.org/obo/DOID_4752	BAO	LOOM
http://purl.obolibrary.org/obo/DOID_4752	HHEAR	LOOM
http://purl.obolibrary.org/obo/DOID_4752	DDSS	LOOM
http://purl.obolibrary.org/obo/DOID_4752	NIFSTD	LOOM
http://purl.obolibrary.org/obo/DOID_4752	MIDO	LOOM
http://purl.obolibrary.org/obo/DOID_4752	FNS-H	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00038305	PMAPP-PMO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#32213	OCHV	LOOM
http://id.nlm.nih.gov/mesh/D019578	MDM	LOOM
http://purl.jp/bio/4/id/200906062420544911	IOBC	LOOM
http://purl.obolibrary.org/obo/ND_0000129	NDDO	LOOM
http://purl.obolibrary.org/obo/ND_0000129	NIO	LOOM
http://uri.neuinfo.org/nif/nifstd/birnlex_12573	NIFDYS	LOOM
http://uri.neuinfo.org/nif/nifstd/birnlex_12573	NIFSTD	LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0393571	MEDLINEPLUS	LOOM