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Medical Subject Headings
| Preferred Name | Didanosine | |
| Synonyms |
Dideoxyinosine Inosine, 2',3'-dideoxy- NSC 612049 Videx ddI (Antiviral) NSC612049 2',3' Dideoxyinosine NSC-612049 2',3'-Dideoxyinosine |
|
| Definitions |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D016049 |
|
| altLabel |
Dideoxyinosine Inosine, 2',3'-dideoxy- NSC 612049 Videx ddI (Antiviral) NSC612049 2',3' Dideoxyinosine NSC-612049 2',3'-Dideoxyinosine
|
|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
|
|
| cui |
C0592249 C0012133 C0702047
|
|
| DC |
1
|
|
| definition |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
|
|
| DX |
19900101
|
|
| HN |
92; was DIDEOXYINOSINE 1990-91
|
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
K3GDH6OH08 0
|
|
| isa |
http://purl.bioontology.org/ontology/MESH/D000963 |
|
| LT |
TRD
|
|
| Machine permutation |
92; was DIDEOXYINOSINE 1990-91
|
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C560264 http://purl.bioontology.org/ontology/MESH/C403505 http://purl.bioontology.org/ontology/MESH/C403504 http://purl.bioontology.org/ontology/MESH/C083218 http://purl.bioontology.org/ontology/MESH/C107380 http://purl.bioontology.org/ontology/MESH/C073075 |
|
| MDA |
19890714
|
|
| MMR |
20170524
|
|
| MN |
D13.570.583.616.130 D13.570.230.500.090 D03.633.100.759.590.616.130 D13.570.800.573.130
|
|
| notation |
D016049
|
|
| OL |
use DIDANOSINE to search DIDEOXYINOSINE 1990-91
|
|
| PA |
D018894 D019380 D000963
|
|
| prefLabel |
Didanosine
|
|
| RR |
69655-05-6 (Didanosine)
|
|
| TERMUI |
T047684 T047683 T047688 T047685 T047686 T047687
|
|
| TH |
US USAN (1990) MX UK NL CA NLM (1990) FDA SRS (2014) ES NLM (1992) INN (19XX) DE AU USP (19XX) BAN (19XX) FR IE
|
|
| tui |
T114 T121
|
|
| subClassOf |
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