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Medical Subject Headings
| Preferred Name | Cilastatin | |
| Synonyms |
MK 0791 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))- Cilastatin Sodium Cilastatin Monosodium Salt MK-791 Monosodium Salt, Cilastatin MK 791 MK791 Sodium, Cilastatin MK0791 Salt, Cilastatin Monosodium |
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| Definitions |
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D015377 |
|
| altLabel |
MK 0791 2-Heptenoic acid, 7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-, (R-(R*,S*-(Z)))- Cilastatin Sodium Cilastatin Monosodium Salt MK-791 Monosodium Salt, Cilastatin MK 791 MK791 Sodium, Cilastatin MK0791 Salt, Cilastatin Monosodium
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|
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
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|
| cui |
C0282395 C0795737 C0008777
|
|
| DC |
1
|
|
| definition |
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
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|
| DX |
19890101
|
|
| HN |
89
|
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
141A6AMN38 5428WXZ74M 0
|
|
| isa | ||
| Machine permutation |
89
|
|
| Mapped from | ||
| MDA |
19880603
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|
| MMR |
20160628
|
|
| MN |
D10.251.355.325.200 D02.455.426.392.368.533.200
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|
| notation |
D015377
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|
| PA |
D011480
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|
| prefLabel |
Cilastatin
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|
| RR |
81129-83-1 (mono-Na salt) 82009-34-5 (Cilastatin) 5428WXZ74M
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|
| TERMUI |
T045335 T359723 T045337 T045338 T045336 T045339
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|
| TH |
NLM (1999) USAN (1986) FDA SRS (2014) UNK (19XX) INN (19XX) USP (19XX) BAN (19XX)
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|
| tui |
T109 T121
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| subClassOf |
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