Medical Subject Headings

Last uploaded: August 28, 2024

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Preferred Name	Zidovudine
Synonyms	AZT Antiviral BWA509U 3' Azido 2',3' Dideoxythymidine Thymidine, 3'-azido-3'-deoxy- Azidothymidine AZT, Antiviral AZT (Antiviral) Antiviral AZT BW A509U BWA-509U Retrovir 3'-Azido-2',3'-Dideoxythymidine 3' Azido 3' deoxythymidine BWA 509U 3'-Azido-3'-deoxythymidine
Definitions	A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
ID	http://purl.bioontology.org/ontology/MESH/D015215
altLabel	AZT Antiviral BWA509U 3' Azido 2',3' Dideoxythymidine Thymidine, 3'-azido-3'-deoxy- Azidothymidine AZT, Antiviral AZT (Antiviral) Antiviral AZT BW A509U BWA-509U Retrovir 3'-Azido-2',3'-Dideoxythymidine 3' Azido 3' deoxythymidine BWA 509U 3'-Azido-3'-deoxythymidine
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0043474 C0701305 C0699576
DC	1
definition	A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
DX	19890101
HN	89
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	4B9XT59T7S 0
isa	http://purl.bioontology.org/ontology/MESH/D000963 http://purl.bioontology.org/ontology/MESH/D018894 http://purl.bioontology.org/ontology/MESH/D019380
LT	TRD
Machine permutation	89
Mapped from	http://purl.bioontology.org/ontology/MESH/C097974 http://purl.bioontology.org/ontology/MESH/C097972 http://purl.bioontology.org/ontology/MESH/C097973 http://purl.bioontology.org/ontology/MESH/C477810 http://purl.bioontology.org/ontology/MESH/C056534 http://purl.bioontology.org/ontology/MESH/C488806 http://purl.bioontology.org/ontology/MESH/C480501 http://purl.bioontology.org/ontology/MESH/C480508 http://purl.bioontology.org/ontology/MESH/C109078 http://purl.bioontology.org/ontology/MESH/C057287 http://purl.bioontology.org/ontology/MESH/C057288 http://purl.bioontology.org/ontology/MESH/C069379 http://purl.bioontology.org/ontology/MESH/C052873 http://purl.bioontology.org/ontology/MESH/C551384 http://purl.bioontology.org/ontology/MESH/C119903 http://purl.bioontology.org/ontology/MESH/C088420 http://purl.bioontology.org/ontology/MESH/C427733 http://purl.bioontology.org/ontology/MESH/C427732 http://purl.bioontology.org/ontology/MESH/C000614922 http://purl.bioontology.org/ontology/MESH/C077692 http://purl.bioontology.org/ontology/MESH/C408972 http://purl.bioontology.org/ontology/MESH/C098203 http://purl.bioontology.org/ontology/MESH/C118768 http://purl.bioontology.org/ontology/MESH/C118767 http://purl.bioontology.org/ontology/MESH/C055886 http://purl.bioontology.org/ontology/MESH/C093974 http://purl.bioontology.org/ontology/MESH/C067821 http://purl.bioontology.org/ontology/MESH/C101737 http://purl.bioontology.org/ontology/MESH/C495110 http://purl.bioontology.org/ontology/MESH/C062451 http://purl.bioontology.org/ontology/MESH/C477800 http://purl.bioontology.org/ontology/MESH/C418262 http://purl.bioontology.org/ontology/MESH/C481863 http://purl.bioontology.org/ontology/MESH/C074906 http://purl.bioontology.org/ontology/MESH/C069652 http://purl.bioontology.org/ontology/MESH/C069651 http://purl.bioontology.org/ontology/MESH/C069653 http://purl.bioontology.org/ontology/MESH/C000604073 http://purl.bioontology.org/ontology/MESH/C072200 http://purl.bioontology.org/ontology/MESH/C023822 http://purl.bioontology.org/ontology/MESH/C401422 http://purl.bioontology.org/ontology/MESH/C075867 http://purl.bioontology.org/ontology/MESH/C075866 http://purl.bioontology.org/ontology/MESH/C068369 http://purl.bioontology.org/ontology/MESH/C068368 http://purl.bioontology.org/ontology/MESH/C115827 http://purl.bioontology.org/ontology/MESH/C065056 http://purl.bioontology.org/ontology/MESH/C065054 http://purl.bioontology.org/ontology/MESH/C480510 http://purl.bioontology.org/ontology/MESH/C089812 http://purl.bioontology.org/ontology/MESH/C089811 http://purl.bioontology.org/ontology/MESH/C423346 http://purl.bioontology.org/ontology/MESH/C114569 http://purl.bioontology.org/ontology/MESH/C098899 http://purl.bioontology.org/ontology/MESH/C409864 http://purl.bioontology.org/ontology/MESH/C409865 http://purl.bioontology.org/ontology/MESH/C075088 http://purl.bioontology.org/ontology/MESH/C114570 http://purl.bioontology.org/ontology/MESH/C504684 http://purl.bioontology.org/ontology/MESH/C501870 http://purl.bioontology.org/ontology/MESH/C081566 http://purl.bioontology.org/ontology/MESH/C081130 http://purl.bioontology.org/ontology/MESH/C058104 http://purl.bioontology.org/ontology/MESH/C064181 http://purl.bioontology.org/ontology/MESH/C064423 http://purl.bioontology.org/ontology/MESH/C437603 http://purl.bioontology.org/ontology/MESH/C421943 http://purl.bioontology.org/ontology/MESH/C421944 http://purl.bioontology.org/ontology/MESH/C067831 http://purl.bioontology.org/ontology/MESH/C546229 http://purl.bioontology.org/ontology/MESH/C064771 http://purl.bioontology.org/ontology/MESH/C064770 http://purl.bioontology.org/ontology/MESH/C060357 http://purl.bioontology.org/ontology/MESH/C110365 http://purl.bioontology.org/ontology/MESH/C053667 http://purl.bioontology.org/ontology/MESH/C068377 http://purl.bioontology.org/ontology/MESH/C076203 http://purl.bioontology.org/ontology/MESH/C097969 http://purl.bioontology.org/ontology/MESH/C414944 http://purl.bioontology.org/ontology/MESH/C416423 http://purl.bioontology.org/ontology/MESH/C520668 http://purl.bioontology.org/ontology/MESH/C541613 http://purl.bioontology.org/ontology/MESH/C058803 http://purl.bioontology.org/ontology/MESH/C106062 http://purl.bioontology.org/ontology/MESH/C578918 http://purl.bioontology.org/ontology/MESH/C518807
MDA	19880509
MMR	20160601
MN	D03.383.742.680.705.950 D13.570.230.855.950 D13.570.230.500.950 D13.570.685.705.950
notation	D015215
PA	D018894 D019380 D000963
prefLabel	Zidovudine
RR	30516-87-1 (Zidovudine)
TERMUI	T044490 T044489 T044498 T044494 T044493 T044491 T044496 T044492 T044497 T044495
TH	NLM (1997) CA FDA SRS (2014) ES UNK (19XX) INN (19XX) DE AU NLM (2007) USAN (1987) USP (19XX) BAN (19XX) FR
tui	T114 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D015224 http://purl.bioontology.org/ontology/MESH/D013936

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RXNORM/11413	RXNORM	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000040121	PDQ	CUI
http://purl.bioontology.org/ontology/RCD/x02pS	RCD	CUI
http://purl.bioontology.org/ontology/RCD/ei5..	RCD	CUI
http://purl.bioontology.org/ontology/LNC/LP16744-2	LOINC	CUI
http://purl.bioontology.org/ontology/LNC/MTHU013874	LOINC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/27479000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/387151007	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147622	NDFRT	CUI
http://purl.bioontology.org/ontology/ATC/J05AF01	ATC	CUI
http://purl.bioontology.org/ontology/SNMI/C-55B60	SNMI	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000040121	PDQ	CUI
http://purl.bioontology.org/ontology/CSP/2109-4800	CRISP	CUI
http://purl.bioontology.org/ontology/VANDF/4019502	VANDF	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387151007	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDDF/003019	NDDF	CUI
http://purl.bioontology.org/ontology/MSHFRE/D015215	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/27479000	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006933	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D015215	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/202791	RXNORM	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000040121	PDQ	CUI
http://purl.bioontology.org/ontology/CSP/2109-4800	CRISP	CUI
http://purl.bioontology.org/ontology/RXNORM/11413	RXNORM	LOOM
http://purl.obolibrary.org/obo/OMIT_0016006	OMIT	LOOM
http://stirdf.jst.go.jp/id/200907007102849056	IOBC	LOOM
http://purl.jp/bio/4/id/200906043535188812	IOBC	LOOM
http://purl.obolibrary.org/obo/ARO_3007687	ARO	LOOM
http://purl.obolibrary.org/obo/NCIT_C947	BERO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018396	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	BAO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	GSSO	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_10110	ODNAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.500.950	RH-MESH	LOOM
http://www.drugbank.ca/drugs/DB00495	FTC	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147622	ODAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.855.950	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C947	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015215	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP16744-2	LOINC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013874	LOINC	LOOM
http://www.co-ode.org/ontologies/galen#Zidovudine	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13273	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.685.705.950	RH-MESH	LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Zidovudine	SEPON	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147622	NDFRT	LOOM
http://purl.bioontology.org/ontology/ATC/J05AF01	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D015215	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.680.705.950	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB00495	MDM	LOOM
http://purl.bioontology.org/ontology/SNMI/C-55B60	SNMI	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040121	PDQ	LOOM
http://purl.bioontology.org/ontology/CSP/2109-4800	CRISP	LOOM
http://purl.bioontology.org/ontology/VANDF/4019502	VANDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387151007	SNOMEDCT	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Zidovudine	APAONTO	LOOM