loading...| Preferred Name |
Purpura, Thrombotic Thrombocytopenic |
|
| Synonyms |
Thrombotic Thrombopenic Purpura |
|
| Definitions |
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D011697 |
|
| altLabel |
Thrombotic Thrombopenic Purpura Purpura, Thrombotic Thrombopenic Familial Thrombotic Microangiopathy Thrombotic Thrombocytopenic Purpura, Congenital Familial Thrombotic Thrombocytopenic Purpura Moschcowitz Disease Thrombocytopenic Purpura, Thrombotic Schulman Upshaw Syndrome Microangiopathic Hemolytic Anemia, Congenital Thrombopenic Purpura, Thrombotic Thrombotic Thrombocytopenic Purpura Upshaw Factor, Deficiency of Moschkowitz Disease Microangiopathy, Familial Thrombotic Familial Thrombotic Thrombocytopenia Purpura Schulman-Upshaw Syndrome Upshaw-Schulman Syndrome Congenital Thrombotic Thrombocytopenic Purpura Upshaw Schulman Syndrome Thrombotic Microangiopathy, Familial Thrombotic Thrombocytopenic Purpura, Familial |
|
| AQL |
BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI |
|
| cui |
C1956258 C1268935 C0034155 |
|
| DC |
1 |
|
| definition |
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases. |
|
| DX |
19650101 |
|
| HN |
1986; use PURPURA, THROMBOTIC THROMBOPENIC 1965-1985 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000178 http://purl.bioontology.org/ontology/MESH/Q000175 http://purl.bioontology.org/ontology/MESH/Q000628 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000139 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000517 http://purl.bioontology.org/ontology/MESH/Q000662 http://purl.bioontology.org/ontology/MESH/Q000469 http://purl.bioontology.org/ontology/MESH/Q000151 http://purl.bioontology.org/ontology/MESH/Q000150 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000196 http://purl.bioontology.org/ontology/MESH/Q000473 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000451 http://purl.bioontology.org/ontology/MESH/Q000453 http://purl.bioontology.org/ontology/MESH/Q000534 http://purl.bioontology.org/ontology/MESH/Q000532 http://purl.bioontology.org/ontology/MESH/Q000503 http://purl.bioontology.org/ontology/MESH/Q000188 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000201 http://purl.bioontology.org/ontology/MESH/Q000209 http://purl.bioontology.org/ontology/MESH/Q000208 http://purl.bioontology.org/ontology/MESH/Q000601 http://purl.bioontology.org/ontology/MESH/Q000000981 http://purl.bioontology.org/ontology/MESH/Q000652 |
|
| Machine permutation |
1986; see PURPURA, THROMBOTIC THROMBOPENIC 1965-1985 |
|
| Mapped from | ||
| MDA |
19990101 |
|
| MMR |
20230226 |
|
| MN |
C15.378.100.802.687.680 C15.378.925.850 C23.550.414.950.687.680 C15.378.243.937.925.750.680 C15.378.140.855.925.750.680 C23.888.885.687.687.680 |
|
| notation |
D011697 |
|
| prefLabel |
Purpura, Thrombotic Thrombocytopenic |
|
| TERMUI |
T842588 T034585 T843443 T679350 T034586 T750375 T812539 T781563 T679352 T679351 T034587 T781564 T679329 T781565 T750374 |
|
| TH |
OMIM (2013) NLM (2008) NLM (2012) NLM (1992) UNK (19XX) NLM (2010) GHR (2014) NLM (1964) NLM (2014) ORD (2010) |
|
| tui |
T047 |
|
| subClassOf |