Medical Subject Headings

Last uploaded: January 31, 2024

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Preferred Name	Prothrombin
Synonyms	Factor, Differentiation Reversal
Definitions	A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
ID	http://purl.bioontology.org/ontology/MESH/D011516
altLabel	Factor, Differentiation Reversal Differentiation Reversal Factor Factor II Blood Coagulation Factor II II, Coagulation Factor Factor II, Coagulation Blood-coagulation factor II Coagulation Factor II
AN	a blood coag factor; an enzyme precursor
AQL	AA AD AE AG AI AN BI CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0033706
DC	1
definition	A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
DX	19660101
EC	deficiency:Hypoprothrombinemias
FX	D003029
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	9001-26-7
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D003029
Mapped from	http://purl.bioontology.org/ontology/MESH/C029733 http://purl.bioontology.org/ontology/MESH/C055165 http://purl.bioontology.org/ontology/MESH/C438207 http://purl.bioontology.org/ontology/MESH/C111181 http://purl.bioontology.org/ontology/MESH/C012007 http://purl.bioontology.org/ontology/MESH/C023558 http://purl.bioontology.org/ontology/MESH/C059800 http://purl.bioontology.org/ontology/MESH/C033200 http://purl.bioontology.org/ontology/MESH/C432402 http://purl.bioontology.org/ontology/MESH/C038287 http://purl.bioontology.org/ontology/MESH/C040593 http://purl.bioontology.org/ontology/MESH/C051338 http://purl.bioontology.org/ontology/MESH/C050083 http://purl.bioontology.org/ontology/MESH/C051306 http://purl.bioontology.org/ontology/MESH/C049589 http://purl.bioontology.org/ontology/MESH/C120393 http://purl.bioontology.org/ontology/MESH/C045879 http://purl.bioontology.org/ontology/MESH/C033099 http://purl.bioontology.org/ontology/MESH/C057276 http://purl.bioontology.org/ontology/MESH/C065848 http://purl.bioontology.org/ontology/MESH/C071331 http://purl.bioontology.org/ontology/MESH/C055042 http://purl.bioontology.org/ontology/MESH/C052676 http://purl.bioontology.org/ontology/MESH/C031561 http://purl.bioontology.org/ontology/MESH/C044183 http://purl.bioontology.org/ontology/MESH/C053346 http://purl.bioontology.org/ontology/MESH/C050707 http://purl.bioontology.org/ontology/MESH/C000599051 http://purl.bioontology.org/ontology/MESH/C094282 http://purl.bioontology.org/ontology/MESH/C008208 http://purl.bioontology.org/ontology/MESH/C058765 http://purl.bioontology.org/ontology/MESH/C050961 http://purl.bioontology.org/ontology/MESH/C525441 http://purl.bioontology.org/ontology/MESH/C025337 http://purl.bioontology.org/ontology/MESH/C038872 http://purl.bioontology.org/ontology/MESH/C403412 http://purl.bioontology.org/ontology/MESH/C083543 http://purl.bioontology.org/ontology/MESH/C050800 http://purl.bioontology.org/ontology/MESH/C103120
MDA	19990101
MMR	20190530
MN	D12.776.124.125.800 D12.776.811.243.709 D23.119.945 D08.622.709
notation	D011516
prefLabel	Prothrombin
TERMUI	T034024 T034022 T034021 T034020 T034023
TH	NLM (1966) NLM (1992) UNK (19XX) NLM (1998)
tui	T116 T123 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D001779 http://purl.bioontology.org/ontology/MESH/D004792

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/NDFRT/N0000171497	NDFRT	CUI
http://purl.bioontology.org/ontology/RXNORM/1441688	RXNORM	CUI
http://purl.bioontology.org/ontology/SCTSPA/7348004	SCTSPA	CUI
http://purl.bioontology.org/ontology/RCD/X80W4	RCD	CUI
http://purl.bioontology.org/ontology/LNC/LP16010-8	LOINC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/7348004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D011516	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNMI/F-D7100	SNMI	CUI
http://purl.bioontology.org/ontology/CSP/0437-7626	CRISP	CUI
http://purl.obolibrary.org/obo/PR_000007299	OBA	LOOM
http://purl.obolibrary.org/obo/CHEBI_8583	CHEBI	LOOM
http://purl.obolibrary.org/obo/PR_000007299	OBA	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.622.709	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82273	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.119.945	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10259	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011516	RH-MESH	LOOM
http://purl.jp/bio/4/id/200906054614845014	IOBC	LOOM
http://purl.bioontology.org/ontology/RXNORM/1441688	RXNORM	LOOM
http://www.co-ode.org/ontologies/galen#Prothrombin	GALEN	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00019280	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/OMIT_0012460	OMIT	LOOM
http://purl.bioontology.org/ontology/LNC/LP16010-8	LOINC	LOOM
http://www.semanticweb.org/ontologies/STO.owl#c34c5b83_8e02_46b9_bb42_82651c32683a	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#c34c5b83_8e02_46b9_bb42_82651c32683a	CVAO	LOOM
http://purl.obolibrary.org/obo/MESH_D011516	BERO	LOOM
http://doe-generated-ontology.com/OntoAD#C0033706	ONTOAD	LOOM
https://go.drugbank.com/drugs/DB11311	MDM	LOOM
http://id.nlm.nih.gov/mesh/D011516	MDM	LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571347974240596027	ACVD_ONTOLOGY	LOOM
http://purl.obolibrary.org/obo/dinto_1008	DINTO	LOOM
http://purl.obolibrary.org/obo/NCIT_C82854	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033706	OCHV	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82854	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.124.125.800	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C82273	BERO	LOOM
http://purl.bioontology.org/ontology/MEDDRA/10037038	MEDDRA	LOOM
http://purl.uniprot.org/uniprot/P00734	FTC	LOOM
http://purl.bioontology.org/ontology/CSP/0437-7626	CRISP	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01469	MIO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8583	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8583	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8583	DRON	LOOM
http://purl.obolibrary.org/obo/PR_000007299	PR	LOOM
http://purl.obolibrary.org/obo/PR_000007299	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/PR_000007299	HUPSON	LOOM
http://purl.obolibrary.org/obo/PR_000007299	CIDO	LOOM
http://purl.obolibrary.org/obo/PR_000007299	NIFSTD	LOOM