Link to this page
Medical Subject Headings
| Preferred Name | Lovastatin | |
| Synonyms |
Lovastatin, 1 alpha Isomer Monacolin K Lovastatin, 1 alpha-Isomer 6-Methylcompactin MK-803 Lovastatin, (1 alpha(S*))-Isomer Mevacor Mevinolin MK 803 Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))- alpha-Isomer Lovastatin, 1 6 Methylcompactin 1 alpha-Isomer Lovastatin MK803 |
|
| Definitions |
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D008148 |
|
| altLabel |
Lovastatin, 1 alpha Isomer Monacolin K Lovastatin, 1 alpha-Isomer 6-Methylcompactin MK-803 Lovastatin, (1 alpha(S*))-Isomer Mevacor Mevinolin MK 803 Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))- alpha-Isomer Lovastatin, 1 6 Methylcompactin 1 alpha-Isomer Lovastatin MK803
|
|
| AQL |
AA AD AE AG AI AN BI BL CF CH CL CS EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR
|
|
| cui |
C0733675 C0024027 C0887160 C0728780 C0887159
|
|
| DC |
1
|
|
| definition |
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
|
|
| DX |
19880101
|
|
| HN |
88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
|
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
79952-44-6 79902-41-3 0 9LHU78OQFD
|
|
| isa | ||
| LT |
TRD
|
|
| Machine permutation |
88; MONACOLIN K was indexed under NAPHTHALENES 1981-98 & ANTIBIOTICS 1980
|
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C070474 http://purl.bioontology.org/ontology/MESH/C109012 http://purl.bioontology.org/ontology/MESH/C109011 http://purl.bioontology.org/ontology/MESH/C064146 http://purl.bioontology.org/ontology/MESH/C064145 http://purl.bioontology.org/ontology/MESH/C039122 http://purl.bioontology.org/ontology/MESH/C000601244 http://purl.bioontology.org/ontology/MESH/C040295 http://purl.bioontology.org/ontology/MESH/C012258 http://purl.bioontology.org/ontology/MESH/C031380 http://purl.bioontology.org/ontology/MESH/C068819 |
|
| MDA |
19870504
|
|
| MMR |
20150623
|
|
| MN |
D04.615.638.400 D02.455.426.559.847.638.400
|
|
| notation |
D008148
|
|
| PA |
D019161 D000924
|
|
| prefLabel |
Lovastatin
|
|
| RR |
79902-41-3 (1 alpha-isomer without R*/S* notation) 79952-44-6 ((1 alpha(S*))-isomer) 75330-75-5 (Lovastatin)
|
|
| TERMUI |
T024294 T814218 T024293 T024291 T024290 T024292 T024289 T360285
|
|
| TH |
NLM (1999) NLM (2012) FDA SRS (2014) UNK (19XX) INN (19XX) USAN (1987) USP (19XX) BAN (19XX)
|
|
| tui |
T109 T121
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |