Medical Subject Headings

Last uploaded: August 28, 2024

Preferred Name	Dextromethorphan
Synonyms	Dextromethorphan Hydrobromide, Monohydrate d-Methorphan Dextromethorphan Hydrobromide, (+-)-Isomer Hydrobromide, Dextromethorphan Dextromethorphan Hydrobromide Racemethorphan Dextromethorphan Hydrochloride Dextromethorphan, (+-)-Isomer Hydrochloride, Dextromethorphan Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)- Delsym
Definitions	Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
ID	http://purl.bioontology.org/ontology/MESH/D003915
altLabel	Dextromethorphan Hydrobromide, Monohydrate d-Methorphan Dextromethorphan Hydrobromide, (+-)-Isomer Hydrobromide, Dextromethorphan Dextromethorphan Hydrobromide Racemethorphan Dextromethorphan Hydrochloride Dextromethorphan, (+-)-Isomer Hydrochloride, Dextromethorphan Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)- Delsym
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0011816 C0887411 C0887413 C0350422 C0034505 C0916919 C0011218 C0887412
DC	1
definition	Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
DX	19910101
HN	91(72); was see under LEVORPHANOL 1972-90
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	6700-34-1 6031-86-3 7355X3ROTS 9D2RTI9KYH 351KFH969D 8YB8F78WM1 0 510-53-2
isa	http://purl.bioontology.org/ontology/MESH/D018691 http://purl.bioontology.org/ontology/MESH/D000996
LT	TRD
Machine permutation	91; was see under LEVORPHANOL 1972-90
Mapped from	http://purl.bioontology.org/ontology/MESH/C045626 http://purl.bioontology.org/ontology/MESH/C023705 http://purl.bioontology.org/ontology/MESH/C548636 http://purl.bioontology.org/ontology/MESH/C426724 http://purl.bioontology.org/ontology/MESH/C054116 http://purl.bioontology.org/ontology/MESH/C042497 http://purl.bioontology.org/ontology/MESH/C121608 http://purl.bioontology.org/ontology/MESH/C049111 http://purl.bioontology.org/ontology/MESH/C479098 http://purl.bioontology.org/ontology/MESH/C507057 http://purl.bioontology.org/ontology/MESH/C550887 http://purl.bioontology.org/ontology/MESH/C028657 http://purl.bioontology.org/ontology/MESH/C468112
MDA	19990101
MMR	20230531
MN	D03.633.400.686.212 D03.132.577.249.200 D03.605.497.212 D04.615.723.795.200
notation	D003915
PA	D018691 D000996
prefLabel	Dextromethorphan
RR	125-71-3 (Dextromethorphan) 6031-86-3 (HBr, (+-)-isomer) 18609-21-7 (HCl) 125-68-8 (HBr, cpd w/o isomeric designation) 9D2RTI9KYH 510-53-2 ((+-)-isomer) 351KFH969D 125-69-9 (HBr) 8YB8F78WM1 6700-34-1 (HBr, mono-hydrate)
TERMUI	T360714 T011712 T011715 T360713 T360712 T360716 T011713 T360715 T011711
TH	NLM (1999) FDA SRS (2014) UNK (19XX) INN (19XX) USP (19XX) BAN (19XX)
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D009019

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/LNC/LA28643-7	LOINC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148103	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/725852003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDDF/001653	NDDF	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003915	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/3146	RXNORM	CUI
http://purl.bioontology.org/ontology/NDDF/004427	NDDF	CUI
http://purl.bioontology.org/ontology/LNC/LP16105-6	LOINC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006161	NDFRT	CUI
http://purl.bioontology.org/ontology/VANDF/4018052	VANDF	CUI
http://purl.bioontology.org/ontology/ATC/R05DA09	ATC	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/2016004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387114001	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/2016004	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNMI/C-88130	SNMI	CUI
http://purl.bioontology.org/ontology/LNC/MTHU004183	LOINC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146393	NDFRT	CUI
http://purl.bioontology.org/ontology/SCTSPA/387114001	SCTSPA	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003915	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/3289	RXNORM	CUI
http://purl.bioontology.org/ontology/CSP/4007-0038	CRISP	CUI
http://purl.bioontology.org/ontology/RXNORM/267251	RXNORM	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179729	NDFRT	CUI
http://purl.bioontology.org/ontology/VANDF/4020116	VANDF	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003915	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/725852003	SCTSPA	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003915	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179490	NDFRT	CUI
http://purl.bioontology.org/ontology/RXNORM/102490	RXNORM	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042490	PDQ	CUI
http://purl.bioontology.org/ontology/RCD/cg2..	RCD	CUI
http://purl.bioontology.org/ontology/SCTSPA/387237004	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387237004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/VANDF/4018051	VANDF	CUI
http://purl.bioontology.org/ontology/SNMI/C-88131	SNMI	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003915	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146392	NDFRT	CUI
http://purl.obolibrary.org/obo/CHEBI_4470	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	DRON	LOOM
http://purl.obolibrary.org/obo/MESH_D003915	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/LA28643-7	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.497.212	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.723.795.200	RH-MESH	LOOM
http://purl.jp/bio/4/id/200906042174065480	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3830	OCHV	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0011816	OCHV	LOOM
http://purl.bioontology.org/ontology/NDDF/004427	NDDF	LOOM
http://purl.bioontology.org/ontology/LNC/LP16105-6	LOINC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62022	NCIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4018052	VANDF	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Dextromethorphan	STMSO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	BAO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	DIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4470	HINO	LOOM
http://purl.bioontology.org/ontology/ATC/R05DA09	ATC	LOOM
http://www.drugbank.ca/drugs/DB00514	FTC	LOOM
http://purl.obolibrary.org/obo/dinto_DB00514	DINTO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.577.249.200	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387114001	SNOMEDCT	LOOM
https://go.drugbank.com/drugs/DB00514	MDM	LOOM
http://stirdf.jst.go.jp/id/200907070908698485	IOBC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018025	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-88130	SNMI	LOOM
http://purl.obolibrary.org/obo/OMIT_0005191	OMIT	LOOM
http://www.co-ode.org/ontologies/galen#Dextromethorphan	GALEN	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004183	LOINC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146393	NDFRT	LOOM
http://purl.obolibrary.org/obo/NCIT_C62022	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.549.686.212	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003915	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/3289	RXNORM	LOOM
http://purl.bioontology.org/ontology/CSP/4007-0038	CRISP	LOOM