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Last uploaded: January 31, 2024

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Preferred Name	Camptothecin
Synonyms	Camptothecine 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
Definitions	An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
ID	http://purl.bioontology.org/ontology/MESH/D002166
altLabel	Camptothecine 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
AQL	AA AD AE AG AI AN BI BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0006812
DC	1
definition	An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
DX	19730101
HN	73
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	XT3Z54Z28A
isa	http://purl.bioontology.org/ontology/MESH/D000972 http://purl.bioontology.org/ontology/MESH/D059004
Machine permutation	73
Mapped from	http://purl.bioontology.org/ontology/MESH/C522460 http://purl.bioontology.org/ontology/MESH/C112865 http://purl.bioontology.org/ontology/MESH/C000612743 http://purl.bioontology.org/ontology/MESH/C524373 http://purl.bioontology.org/ontology/MESH/C000610389 http://purl.bioontology.org/ontology/MESH/C028098 http://purl.bioontology.org/ontology/MESH/C121907 http://purl.bioontology.org/ontology/MESH/C000709258 http://purl.bioontology.org/ontology/MESH/C572585 http://purl.bioontology.org/ontology/MESH/C530146 http://purl.bioontology.org/ontology/MESH/C530145 http://purl.bioontology.org/ontology/MESH/C095887 http://purl.bioontology.org/ontology/MESH/C484816 http://purl.bioontology.org/ontology/MESH/C548684 http://purl.bioontology.org/ontology/MESH/C440617 http://purl.bioontology.org/ontology/MESH/C437308 http://purl.bioontology.org/ontology/MESH/C122131 http://purl.bioontology.org/ontology/MESH/C513484 http://purl.bioontology.org/ontology/MESH/C095684 http://purl.bioontology.org/ontology/MESH/C561038 http://purl.bioontology.org/ontology/MESH/C534541 http://purl.bioontology.org/ontology/MESH/C584112 http://purl.bioontology.org/ontology/MESH/C120029 http://purl.bioontology.org/ontology/MESH/C496829 http://purl.bioontology.org/ontology/MESH/C588288 http://purl.bioontology.org/ontology/MESH/C588287 http://purl.bioontology.org/ontology/MESH/C048684 http://purl.bioontology.org/ontology/MESH/C114685 http://purl.bioontology.org/ontology/MESH/C558307 http://purl.bioontology.org/ontology/MESH/C558306 http://purl.bioontology.org/ontology/MESH/C066731 http://purl.bioontology.org/ontology/MESH/C582557 http://purl.bioontology.org/ontology/MESH/C529807 http://purl.bioontology.org/ontology/MESH/C116963 http://purl.bioontology.org/ontology/MESH/C499708 http://purl.bioontology.org/ontology/MESH/C091720 http://purl.bioontology.org/ontology/MESH/C057068 http://purl.bioontology.org/ontology/MESH/C000614160 http://purl.bioontology.org/ontology/MESH/C514334 http://purl.bioontology.org/ontology/MESH/C415575 http://purl.bioontology.org/ontology/MESH/C415573 http://purl.bioontology.org/ontology/MESH/C427229 http://purl.bioontology.org/ontology/MESH/C000611787 http://purl.bioontology.org/ontology/MESH/C066310 http://purl.bioontology.org/ontology/MESH/C066311 http://purl.bioontology.org/ontology/MESH/C531200 http://purl.bioontology.org/ontology/MESH/C542292 http://purl.bioontology.org/ontology/MESH/C079905 http://purl.bioontology.org/ontology/MESH/C483495 http://purl.bioontology.org/ontology/MESH/C483494 http://purl.bioontology.org/ontology/MESH/C433984 http://purl.bioontology.org/ontology/MESH/C120496 http://purl.bioontology.org/ontology/MESH/C120495 http://purl.bioontology.org/ontology/MESH/C120497 http://purl.bioontology.org/ontology/MESH/C115093 http://purl.bioontology.org/ontology/MESH/C100720 http://purl.bioontology.org/ontology/MESH/C478602 http://purl.bioontology.org/ontology/MESH/C000618348 http://purl.bioontology.org/ontology/MESH/C528367 http://purl.bioontology.org/ontology/MESH/C528368 http://purl.bioontology.org/ontology/MESH/C000593914 http://purl.bioontology.org/ontology/MESH/C424962 http://purl.bioontology.org/ontology/MESH/C529642 http://purl.bioontology.org/ontology/MESH/C106003 http://purl.bioontology.org/ontology/MESH/C549429 http://purl.bioontology.org/ontology/MESH/C458822 http://purl.bioontology.org/ontology/MESH/C051891 http://purl.bioontology.org/ontology/MESH/C452060 http://purl.bioontology.org/ontology/MESH/C526467 http://purl.bioontology.org/ontology/MESH/C534422 http://purl.bioontology.org/ontology/MESH/C541284 http://purl.bioontology.org/ontology/MESH/C518862 http://purl.bioontology.org/ontology/MESH/C000589597 http://purl.bioontology.org/ontology/MESH/C480833 http://purl.bioontology.org/ontology/MESH/C480834 http://purl.bioontology.org/ontology/MESH/C522252 http://purl.bioontology.org/ontology/MESH/C586836 http://purl.bioontology.org/ontology/MESH/C577311 http://purl.bioontology.org/ontology/MESH/C506412 http://purl.bioontology.org/ontology/MESH/C532663 http://purl.bioontology.org/ontology/MESH/C113402 http://purl.bioontology.org/ontology/MESH/C441475 http://purl.bioontology.org/ontology/MESH/C501379 http://purl.bioontology.org/ontology/MESH/C520768 http://purl.bioontology.org/ontology/MESH/C097011 http://purl.bioontology.org/ontology/MESH/C544699 http://purl.bioontology.org/ontology/MESH/C400585 http://purl.bioontology.org/ontology/MESH/C511490 http://purl.bioontology.org/ontology/MESH/C511491 http://purl.bioontology.org/ontology/MESH/C519985 http://purl.bioontology.org/ontology/MESH/C406143 http://purl.bioontology.org/ontology/MESH/C062134 http://purl.bioontology.org/ontology/MESH/C062135 http://purl.bioontology.org/ontology/MESH/C546777 http://purl.bioontology.org/ontology/MESH/C515887 http://purl.bioontology.org/ontology/MESH/C402491 http://purl.bioontology.org/ontology/MESH/C110063 http://purl.bioontology.org/ontology/MESH/C000608132 http://purl.bioontology.org/ontology/MESH/C516254 http://purl.bioontology.org/ontology/MESH/C025724 http://purl.bioontology.org/ontology/MESH/C000710748 http://purl.bioontology.org/ontology/MESH/C116718 http://purl.bioontology.org/ontology/MESH/C080125 http://purl.bioontology.org/ontology/MESH/C527042 http://purl.bioontology.org/ontology/MESH/C530309 http://purl.bioontology.org/ontology/MESH/C091719 http://purl.bioontology.org/ontology/MESH/C515446 http://purl.bioontology.org/ontology/MESH/C525022 http://purl.bioontology.org/ontology/MESH/C509829 http://purl.bioontology.org/ontology/MESH/C085084 http://purl.bioontology.org/ontology/MESH/C049800 http://purl.bioontology.org/ontology/MESH/C558738 http://purl.bioontology.org/ontology/MESH/C506451 http://purl.bioontology.org/ontology/MESH/C518184 http://purl.bioontology.org/ontology/MESH/C106646 http://purl.bioontology.org/ontology/MESH/C461385 http://purl.bioontology.org/ontology/MESH/C521106 http://purl.bioontology.org/ontology/MESH/C528970
MDA	19990101
MMR	20130708
MN	D03.132.151
notation	D002166
PA	D000972 D059004
prefLabel	Camptothecin
RR	7689-03-4 (Camptothecin)
TERMUI	T006191 T006192
TH	NLM (1973) NLM (1990) FDA SRS (2014)
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D000470

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D002166	MSHFRE	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000039173	PDQ	CUI
http://purl.bioontology.org/ontology/SCTSPA/95994003	SCTSPA	CUI
http://purl.bioontology.org/ontology/CSP/0091-9414	CRISP	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007999	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/95994003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SNMI/C-30327	SNMI	CUI
http://purl.obolibrary.org/obo/CHEBI_27656	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	OBA	LOOM
http://purl.obolibrary.org/obo/NCIT_C338	BERO	LOOM
http://purl.jp/bio/4/id/200906042968982789	IOBC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039173	PDQ	LOOM
http://purl.bioontology.org/ontology/CSP/0091-9414	CRISP	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/95994003	SNOMEDCT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2330	OCHV	LOOM
http://purl.bioontology.org/ontology/SNMI/C-30327	SNMI	LOOM
http://purl.obolibrary.org/obo/OMIT_0003505	OMIT	LOOM
http://purl.obolibrary.org/obo/MESH_D002166	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_27656	BIOMODELS	LOOM
https://go.drugbank.com/drugs/DB04690	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0006812	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002166	RH-MESH	LOOM
http://stirdf.jst.go.jp/id/200907005209736570	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.151	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018115	PMAPP-PMO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C338	NCIT	LOOM
http://id.nlm.nih.gov/mesh/D002166	MDM	LOOM