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Human Phenotype Ontology
Last uploaded:
January 16, 2025
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| Id | http://purl.obolibrary.org/obo/HP_0000256
http://purl.obolibrary.org/obo/HP_0000256
|
|---|---|
| Preferred Name | Macrocephaly |
| Definitions |
Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium.
Macrocephaly can be due to hydrocephalus (increased CFSF), megalencephaly (increased brain volume) or thickening of the skull. Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles [Hall et al. [2007]], others by standard deviations [Farkas, [1981]]. It is important to add an indication of how far above the normal standard the head circumference is if an accurate assessment of this can be made. Macrocephaly is an absolute term. The term relative macrocephaly can be used when the head size centile exceeds the centile for height, for example, head size at the 75th centile with height at the 5th centile for age and sex.
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| Synonyms |
Big calvaria
Big head
Big skull
Increased size of head
Large skull
Large cranium
Large calvaria
Big cranium
Large head
Increased size of cranium
Increased size of skull
Megacephaly
Macrocrania
Macrocephalus
Large head circumference
See more
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium. |
|---|---|
| label |
Macrocephaly
|
| comment |
Macrocephaly can be due to hydrocephalus (increased CFSF), megalencephaly (increased brain volume) or thickening of the skull. Head circumference is measured from just above the glabella (the most prominent point on the frontal bone above the root of the nose) to the most posterior prominent point of the occipital bone using a tape measure. Some standard charts are organized by centiles [Hall et al. [2007]], others by standard deviations [Farkas, [1981]]. It is important to add an indication of how far above the normal standard the head circumference is if an accurate assessment of this can be made. Macrocephaly is an absolute term. The term relative macrocephaly can be used when the head size centile exceeds the centile for height, for example, head size at the 75th centile with height at the 5th centile for age and sex.
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| prefLabel |
Macrocephaly
|
| database_cross_reference |
Fyler:4335
UMLS:C4255213
UMLS:C4280664
UMLS:C4083076
UMLS:C4280663
|
| notation |
HP:0000256
|
| in_subset | |
| id |
HP:0000256
|
| has_obo_namespace |
human_phenotype
|
| subClassOf | |
| has_alternative_id |
HP:0005496
HP:0005491
HP:0200135
|
| type | |
| has_broad_synonym |
Big calvaria
Big head
Big skull
Increased size of head
Large skull
Large cranium
Large calvaria
Big cranium
See more
See less
|
| has_exact_synonym |
Large head
Increased size of cranium
Increased size of skull
Megacephaly
Macrocrania
Macrocephalus
Large head circumference
See more
See less
|
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