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Homeostasis imbalance process ontology
| Preferred Name | ritonavir | |
| Synonyms |
N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide |
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| Definitions |
An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_45409 |
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| database cross reference |
PMID:11363086 PMID:27993242 CAS:155213-67-5 PMID:9278209 Reaxys:768009 PMID:8568292 PMID:11996889 LINCS:LSM-5623 PMID:11363184 PMID:24202050 PMID:11363517 PMID:11363300 PMID:9140265 PMID:32505227 PMID:11363329 PMID:32690910 PMID:9585800 Drug_Central:2391 PMID:11363397
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|
| definition |
An L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
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|
| formula |
C37H48N6O5S2
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| has role |
http://purl.bioontology.org/ontology/HOIP/HOIP_0039761 http://purl.obolibrary.org/obo/CHEBI_35703 http://purl.obolibrary.org/obo/CHEBI_35660 http://purl.obolibrary.org/obo/CHEBI_36044 |
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| has_exact_synonym |
N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
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|
| label |
ritonavir
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| prefixIRI |
CHEBI:45409
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|
| prefLabel |
ritonavir
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| smiles |
CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1
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| subClassOf |
http://purl.bioontology.org/ontology/HOIP/HOIP_0036054 |
| Delete | Subject | Author | Type | Created |
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