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Human Interaction Network Ontology
| Preferred Name | G1/S Transition | |
| Synonyms |
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| Definitions |
Cyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include proteins involved in the initiation of DNA replication. The two Cyclin E proteins are subjected to ubiquitin-dependent proteolysis, under the control of an E3 ubiquitin ligase known as the SCF. Cyclin A - Cdk2 complexes, which are also regulated by p21Cip1/Waf1 and p27kip1, are likely to be important for continued DNA synthesis, and progression into G2. An additional level of control of Cdk2 is reversible phosphorylation of Threonine-14 (T14) and Tyrosine-15 (Y15), catalyzed by the Wee1 and Myt1 kinases, and dephosphorylation by the three Cdc25 phosphatases, Cdc25A, B and C. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017745 |
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| comment |
Cyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include proteins involved in the initiation of DNA replication. The two Cyclin E proteins are subjected to ubiquitin-dependent proteolysis, under the control of an E3 ubiquitin ligase known as the SCF. Cyclin A - Cdk2 complexes, which are also regulated by p21Cip1/Waf1 and p27kip1, are likely to be important for continued DNA synthesis, and progression into G2. An additional level of control of Cdk2 is reversible phosphorylation of Threonine-14 (T14) and Tyrosine-15 (Y15), catalyzed by the Wee1 and Myt1 kinases, and dephosphorylation by the three Cdc25 phosphatases, Cdc25A, B and C.
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| definition source |
Reactome, http://www.reactome.org
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| label |
G1/S Transition
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| located_in | ||
| prefixIRI |
HINO:0017745
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| prefLabel |
G1/S Transition
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| seeAlso |
ReactomeREACT_1783 GENE ONTOLOGYGO:0000082 Reactome Database ID Release 4369206
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0015245 http://purl.obolibrary.org/obo/HINO_0017748 |
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