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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | G1/S-Specific Transcription | |
| Synonyms |
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| Definitions |
The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D:CDK complexes releases pRb from E2F, inducing E2F-targeted genes such as cyclin E. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0017748 |
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| comment |
The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D:CDK complexes releases pRb from E2F, inducing E2F-targeted genes such as cyclin E.
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| definition source |
Reactome, http://www.reactome.org
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| label |
G1/S-Specific Transcription
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| located_in | ||
| prefixIRI |
HINO:0017748
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| prefLabel |
G1/S-Specific Transcription
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| seeAlso |
GENE ONTOLOGYGO:0000083 ReactomeREACT_683 Reactome Database ID Release 4369205
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