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Human Interaction Network Ontology
| Preferred Name | Attachment of GPI anchor to uPAR | |
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| Definitions |
The mature form of urokinase plasminogen activator receptor (uPAR) is attached to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor (Ploug et al. 1991). As nascent uPAR polypeptide moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves the uPAR polypeptide after residue 305, releasing the carboxyterminal peptide of uPAR and replacing it with an acylated GPI moiety. In a second step, the GPI moiety is deacylated, yielding a uPAR-GPI conjugate that can be efficiently transported to the Golgi apparatus. This transport process and the other events needed to generate fully glycosylated uPAR-GPI associated with the plasma membrane will be annotated in a future release of Reactome. Authored: D'Eustachio, P, 2005-04-04 21:01:34 Edited: D'Eustachio, P, 0000-00-00 00:00:00 |
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http://purl.obolibrary.org/obo/HINO_0016737 |
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| comment |
The mature form of urokinase plasminogen activator receptor (uPAR) is attached to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor (Ploug et al. 1991). As nascent uPAR polypeptide moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves the uPAR polypeptide after residue 305, releasing the carboxyterminal peptide of uPAR and replacing it with an acylated GPI moiety. In a second step, the GPI moiety is deacylated, yielding a uPAR-GPI conjugate that can be efficiently transported to the Golgi apparatus. This transport process and the other events needed to generate fully glycosylated uPAR-GPI associated with the plasma membrane will be annotated in a future release of Reactome. Authored: D'Eustachio, P, 2005-04-04 21:01:34 Edited: D'Eustachio, P, 0000-00-00 00:00:00
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| definition source |
Reactome, http://www.reactome.org Pubmed1846368
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Attachment of GPI anchor to uPAR
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HINO:0016737
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| prefLabel |
Attachment of GPI anchor to uPAR
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| seeAlso |
Reactome Database ID Release 43162791 ReactomeREACT_1830 GENE ONTOLOGYGO:0016255
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