loading...| Preferred Name |
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
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| Synonyms |
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| Definitions |
Reviewed: Stafford, DW, 0000-00-00 00:00:00 A number of proteins, including eight required for normal blood clot formation and its regulation (Prothrombin (factor II), factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas6) share a sequence motif rich in glutamate residues near their amino termini. Carboxylation of the glutamate residues within this motif followed by removal of an aminoterminal propeptide is required for each of these proteins to function. These modifications occur as the proteins move through the endoplasmic reticulum and Golgi apparatus. Authored: D'Eustachio, P, 2005-03-17 16:24:57 Edited: D'Eustachio, P, 0000-00-00 00:00:00 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016727 |
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| comment |
Reviewed: Stafford, DW, 0000-00-00 00:00:00 A number of proteins, including eight required for normal blood clot formation and its regulation (Prothrombin (factor II), factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas6) share a sequence motif rich in glutamate residues near their amino termini. Carboxylation of the glutamate residues within this motif followed by removal of an aminoterminal propeptide is required for each of these proteins to function. These modifications occur as the proteins move through the endoplasmic reticulum and Golgi apparatus. Authored: D'Eustachio, P, 2005-03-17 16:24:57 Edited: D'Eustachio, P, 0000-00-00 00:00:00 |
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| definition source |
Reactome, http://www.reactome.org |
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| label |
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
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| located_in | ||
| prefixIRI |
HINO:0016727 |
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| prefLabel |
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
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| seeAlso |
GENE ONTOLOGYGO:0017187 ReactomeREACT_1132 Reactome Database ID Release 43159854 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0016726 http://purl.obolibrary.org/obo/HINO_0016722 |