loading...| Preferred Name |
Gamma-carboxylation of protein precursors |
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| Definitions |
Authored: D'Eustachio, P, 2005-03-17 16:24:57 Gamma-carboxylation of a cluster of glutamate residues near the amino termini of thrombin, factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas 6 is required for these proteins to bind Ca++ and function efficiently in blood clotting. A single enzyme, vitamin K-dependent gamma-carboxylase, catalyzes the gamma-carboxylation of all eight proteins involved in clotting (Morris et al. 1995; Brenner et al. 1998; Spronk et al. 2000). In the carboxylation reaction, the enzyme binds its substrate protein via a sequence motif on the amino terminal side of the glutamate residues to be carboxylated (Furie et al. 1999), then processively carboxylates all glutamates in the cluster before releasing the substrate (Morris et al. 1995; Berkner 2000; Stenina et al. 2001). The reaction occurs in the endoplasmic reticulum (Bristol et al. 1996). Edited: D'Eustachio, P, 0000-00-00 00:00:00 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016726 |
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| comment |
Authored: D'Eustachio, P, 2005-03-17 16:24:57 Gamma-carboxylation of a cluster of glutamate residues near the amino termini of thrombin, factor VII, factor IX, factor X, protein C, protein S, protein Z, and Gas 6 is required for these proteins to bind Ca++ and function efficiently in blood clotting. A single enzyme, vitamin K-dependent gamma-carboxylase, catalyzes the gamma-carboxylation of all eight proteins involved in clotting (Morris et al. 1995; Brenner et al. 1998; Spronk et al. 2000). In the carboxylation reaction, the enzyme binds its substrate protein via a sequence motif on the amino terminal side of the glutamate residues to be carboxylated (Furie et al. 1999), then processively carboxylates all glutamates in the cluster before releasing the substrate (Morris et al. 1995; Berkner 2000; Stenina et al. 2001). The reaction occurs in the endoplasmic reticulum (Bristol et al. 1996). Edited: D'Eustachio, P, 0000-00-00 00:00:00 |
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| definition source |
Pubmed11071668 Pubmed8530480 Reactome, http://www.reactome.org Pubmed8839851 Pubmed9845520 Pubmed11513608 Pubmed10917896 Pubmed10068650 |
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| label |
Gamma-carboxylation of protein precursors |
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| prefixIRI |
HINO:0016726 |
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Gamma-carboxylation of protein precursors |
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| seeAlso |
GENE ONTOLOGYGO:0017187 Reactome Database ID Release 43159740 ReactomeREACT_1050 |
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http://purl.obolibrary.org/obo/HINO_0025900 http://purl.obolibrary.org/obo/HINO_0025902 http://purl.obolibrary.org/obo/HINO_0025901 http://purl.obolibrary.org/obo/HINO_0025903 http://purl.obolibrary.org/obo/HINO_0025898 http://purl.obolibrary.org/obo/HINO_0025899 |