loading...| Preferred Name |
Removal of aminoterminal propeptides from gamma-carboxylated proteins |
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| Synonyms |
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| Definitions |
Authored: D'Eustachio, P, 2005-03-17 16:24:57 Furin is an endopeptidase localized to the Golgi membrane that cleaves many proteins on the carboxyterminal side of the sequence motif Arg-[any residue]-(Lys or Arg)-Arg (Jones et al. 1995; Leduc et al. 1992). In the case of gamma-carboxylated proteins, if this cleavage does not occur, the proteins are still secreted but do not function properly (Bristol et al. 1993; Lind et al. 1997). The aminoterminal fragments, "propeptides", generated in this reaction have no known function; the carboxylated, cleaved proteins are delivered to the cell membrane or secreted from the cell via pathways to be annotated in a future release of Reactome. Edited: D'Eustachio, P, 0000-00-00 00:00:00 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016721 |
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| comment |
Authored: D'Eustachio, P, 2005-03-17 16:24:57 Furin is an endopeptidase localized to the Golgi membrane that cleaves many proteins on the carboxyterminal side of the sequence motif Arg-[any residue]-(Lys or Arg)-Arg (Jones et al. 1995; Leduc et al. 1992). In the case of gamma-carboxylated proteins, if this cleavage does not occur, the proteins are still secreted but do not function properly (Bristol et al. 1993; Lind et al. 1997). The aminoterminal fragments, "propeptides", generated in this reaction have no known function; the carboxylated, cleaved proteins are delivered to the cell membrane or secreted from the cell via pathways to be annotated in a future release of Reactome. Edited: D'Eustachio, P, 0000-00-00 00:00:00 |
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| definition source |
Reactome, http://www.reactome.org Pubmed8463288 Pubmed8846780 Pubmed9108399 Pubmed1629222 |
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| label |
Removal of aminoterminal propeptides from gamma-carboxylated proteins |
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| located_in | ||
| prefixIRI |
HINO:0016721 |
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| prefLabel |
Removal of aminoterminal propeptides from gamma-carboxylated proteins |
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| seeAlso |
GENE ONTOLOGYGO:0006508 ReactomeREACT_733 Reactome Database ID Release 43159782 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0025924 http://purl.obolibrary.org/obo/HINO_0025922 http://purl.obolibrary.org/obo/HINO_0025925 http://purl.obolibrary.org/obo/HINO_0025920 http://purl.obolibrary.org/obo/HINO_0025923 http://purl.obolibrary.org/obo/HINO_0025921 |