Preferred Name |
Post-translational modification: synthesis of GPI-anchored proteins |
|
Synonyms |
|
|
Definitions |
Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.<p>As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus. |
|
ID |
http://purl.obolibrary.org/obo/HINO_0016719 |
|
comment |
Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring. As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus. |
|
definition source |
Reactome, http://www.reactome.org |
|
label |
Post-translational modification: synthesis of GPI-anchored proteins |
|
located_in | ||
prefixIRI |
HINO:0016719 |
|
prefLabel |
Post-translational modification: synthesis of GPI-anchored proteins |
|
seeAlso |
ReactomeREACT_1853 GENE ONTOLOGYGO:0006501 Reactome Database ID Release 43163125 |
|
subClassOf | ||
has_part |
http://purl.obolibrary.org/obo/HINO_0016737 |