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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Post-translational modification: synthesis of GPI-anchored proteins | |
| Synonyms |
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| Definitions |
Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.<p>As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016719 |
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| comment |
Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.<p>As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus.
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| definition source |
Reactome, http://www.reactome.org
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| label |
Post-translational modification: synthesis of GPI-anchored proteins
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| located_in | ||
| prefixIRI |
HINO:0016719
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| prefLabel |
Post-translational modification: synthesis of GPI-anchored proteins
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| seeAlso |
ReactomeREACT_1853 GENE ONTOLOGYGO:0006501 Reactome Database ID Release 43163125
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0016737 |
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