loading...| Preferred Name |
Phospholipase C-mediated cascade |
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| Synonyms |
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| Definitions |
Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases.<br> Authored: de Bono, B, 2007-01-10 10:27:18 Edited: Jupe, S, 2010-02-03 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016041 |
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| comment |
Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases. Authored: de Bono, B, 2007-01-10 10:27:18 Edited: Jupe, S, 2010-02-03 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 |
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| definition source |
Reactome, http://www.reactome.org Pubmed10579907 Pubmed1656221 Pubmed15863030 |
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| label |
Phospholipase C-mediated cascade |
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| located_in | ||
| prefixIRI |
HINO:0016041 |
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| prefLabel |
Phospholipase C-mediated cascade |
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| seeAlso |
Reactome Database ID Release 43190347 ReactomeREACT_21310 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0008982 http://purl.obolibrary.org/obo/HINO_0008981 |