loading...| Preferred Name |
Activated FGFR binds PLC-gamma |
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| Definitions |
Authored: de Bono, B, 2007-01-10 10:27:18 Recruitment of PLC-gamma by FGF receptors has been best studied in FGFR1c signaling, where it has been shown that autophosphorylation of Tyr766 in the C-terminal tail of FGFR1c creates a specific binding site for the SH2 domain of PLC-gamma. A mutant FGFR1c in which Y766 is replaced by phenylalanine is unable to activate PI hydrolysis and Ca2+ release in response to FGF stimulation. Membrane recruitment of PLC-gamma is also aided by binding of the Pleckstrin homology (PH) domain of this enzyme to PtIns(3,4,5) P3 molecules that are generated in response to PI-3 kinase stimulation. By sequence comparison, Y766 is conserved in all FGFR isoforms, and PLC-gamma signaling is observed, to a greater or lesser extent, downstream of all FGFR receptors upon stimulation with FGFs. Edited: Jupe, S, 2010-02-03 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 |
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http://purl.obolibrary.org/obo/HINO_0008981 |
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| comment |
Authored: de Bono, B, 2007-01-10 10:27:18 Recruitment of PLC-gamma by FGF receptors has been best studied in FGFR1c signaling, where it has been shown that autophosphorylation of Tyr766 in the C-terminal tail of FGFR1c creates a specific binding site for the SH2 domain of PLC-gamma. A mutant FGFR1c in which Y766 is replaced by phenylalanine is unable to activate PI hydrolysis and Ca2+ release in response to FGF stimulation. Membrane recruitment of PLC-gamma is also aided by binding of the Pleckstrin homology (PH) domain of this enzyme to PtIns(3,4,5) P3 molecules that are generated in response to PI-3 kinase stimulation. By sequence comparison, Y766 is conserved in all FGFR isoforms, and PLC-gamma signaling is observed, to a greater or lesser extent, downstream of all FGFR receptors upon stimulation with FGFs. Edited: Jupe, S, 2010-02-03 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 |
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| definition source |
Pubmed16844695 Pubmed9430633 Pubmed10652257 Reactome, http://www.reactome.org Pubmed1656221 |
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http://purl.obolibrary.org/obo/HINO_0004952 |
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| label |
Activated FGFR binds PLC-gamma |
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| prefixIRI |
HINO:0008981 |
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| prefLabel |
Activated FGFR binds PLC-gamma |
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| seeAlso |
ReactomeREACT_21398 Reactome Database ID Release 43190896 |
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