Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.<p> Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.<p> This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury. Authored: Ouwehand, W.H., 2007-11-12 16:45:54 Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00

http://purl.obolibrary.org/obo/HINO_0015307

Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.

Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.

This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury.

Authored: Ouwehand, W.H., 2007-11-12 16:45:54

Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00

Pubmed8578462

Pubmed16115029

Pubmed14615387

Reactome, http://www.reactome.org

Pubmed10798271

Pubmed11282294

Pubmed17525755

Cell surface interactions at the vascular wall

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0015307

Cell surface interactions at the vascular wall

ReactomeREACT_12051

GENE ONTOLOGYGO:0050900

Reactome Database ID Release 43202733

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