loading...| Preferred Name | Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen | |
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Reviewed: Poole, AW, 2009-11-02 GPVI receptor has little affinity for soluble forms of collagen but binds collagen fibrils. Recent structural models indicate that each GPVI receptor complex could bind up to 3 collagen fibrils (Jung & Moroi 2008). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FceRIgamma complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FceRIgamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation. Authored: Ouwehand, W.H., 2007-11-12 16:45:54 Reviewed: Harper, MT, 2009-11-02 Edited: Jupe, S, 2009-11-02 Reviewed: Jones, ML, 2009-11-02 |
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http://purl.obolibrary.org/obo/HINO_0014496 |
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Reviewed: Poole, AW, 2009-11-02 GPVI receptor has little affinity for soluble forms of collagen but binds collagen fibrils. Recent structural models indicate that each GPVI receptor complex could bind up to 3 collagen fibrils (Jung & Moroi 2008). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FceRIgamma complex in platelets and initiate platelet activation through phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in the FceRIgamma chain, leading to binding and activation of the tyrosine kinase Syk. Downstream of Syk, a series of adapter molecules and effectors lead to platelet activation. Authored: Ouwehand, W.H., 2007-11-12 16:45:54 Reviewed: Harper, MT, 2009-11-02 Edited: Jupe, S, 2009-11-02 Reviewed: Jones, ML, 2009-11-02 |
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| definition source |
Pubmed9295288 Pubmed19065783 Reactome, http://www.reactome.org |
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Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen |
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HINO:0014496 |
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Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen |
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| seeAlso |
ReactomeREACT_1088 Reactome Database ID Release 43114577 |
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