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Gene Ontology Extension
| Preferred Name | signal transduction | |
| Synonyms |
signaling cascade signalling cascade signaling pathway signalling pathway |
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| Definitions |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. |
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| ID |
http://purl.obolibrary.org/obo/GO_0007165 |
|
| comment |
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
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| database_cross_reference |
Reactome:1253589 Reactome:1393403 Reactome:1450988 Reactome:1417898 Reactome:1353201 Reactome:1373377 Reactome:212718 Wikipedia:Signal_transduction Reactome:1327107
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|
| definition |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
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| has_alternative_id |
GO:0023033
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| has_narrow_synonym |
signaling cascade signalling cascade
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| has_obo_namespace |
biological_process
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| has_related_synonym |
signaling pathway signalling pathway
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|
| id |
GO:0007165
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|
| in_subset |
http://purl.obolibrary.org/obo/go#goslim_generic http://purl.obolibrary.org/obo/go#goslim_candida http://purl.obolibrary.org/obo/go#goslim_plant |
|
| label |
signal transduction
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|
| notation |
GO:0007165
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| part_of | ||
| prefLabel |
signal transduction
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|
| treeView |
http://purl.obolibrary.org/obo/GO_0050794 |
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| subClassOf |
| Delete | Subject | Author | Type | Created |
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