loading...| Preferred Name |
hepatocellular carcinoma |
|
| Synonyms |
primary carcinoma of the liver cells hepatoblastoma, somatic carcinoma of liver carcinoma of liver cells hepatocellular carcinoma, somatic hepatocellular carcinoma hepatocellular carcinoma, childhood type, somatic carcinoma, hepatocellular, malignant liver carcinoma hepatocellular adenocarcinoma primary carcinoma of liver cells cancer, hepatocellular hepatocellular cancer hepatocellular cancer, somatic carcinoma of the liver cells liver cell carcinoma liver cell cancer (hepatocellular carcinoma) HCC hepatoma hepatoblastoma caused by somatic mutation liver and intrahepatic bile duct carcinoma liver cancer hepatoblastoma adult hepatoma adult primary hepatocellular carcinoma |
|
| Definitions |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
|
| ID |
http://purl.obolibrary.org/obo/MONDO_0007256 |
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| closeMatch | ||
| disease arises from alteration in structure | ||
| exactMatch |
http://purl.obolibrary.org/obo/NCIT_C3099 http://identifiers.org/mesh/D006528 http://www.orpha.net/ORDO/Orphanet_88673 http://purl.obolibrary.org/obo/DOID_686 |
|
| hasDbXref |
OMIM:114550 ICDO:8170/3 MESH:D006528 Orphanet:88673 EFO:0000182 ONCOTREE:HCC MedDRA:10049010 DOID:684 DOID:686 GARD:16773 NCIT:C3099 NORD:1907 |
|
| hasExactSynonym |
primary carcinoma of the liver cells hepatoblastoma, somatic carcinoma of liver carcinoma of liver cells hepatocellular carcinoma, somatic hepatocellular carcinoma hepatocellular carcinoma, childhood type, somatic carcinoma, hepatocellular, malignant liver carcinoma hepatocellular adenocarcinoma primary carcinoma of liver cells cancer, hepatocellular hepatocellular cancer hepatocellular cancer, somatic carcinoma of the liver cells liver cell carcinoma liver cell cancer (hepatocellular carcinoma) HCC hepatoma |
|
| hasNarrowSynonym |
adult hepatoma adult primary hepatocellular carcinoma |
|
| hasRelatedSynonym |
hepatoblastoma caused by somatic mutation liver and intrahepatic bile duct carcinoma liver cancer hepatoblastoma |
|
| IAO_0000115 |
A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. |
|
| IAO_0000233 | ||
| id |
MONDO:0007256 |
|
| inSubset |
http://purl.obolibrary.org/obo/mondo#ordo_disease http://purl.obolibrary.org/obo/mondo#rare http://purl.obolibrary.org/obo/mondo#nord_rare |
|
| label |
hepatocellular carcinoma |
|
| notation |
MONDO:0007256 |
|
| prefLabel |
hepatocellular carcinoma |
|
| subClassOf |
http://purl.obolibrary.org/obo/MONDO_0004993 |