loading...| Preferred Name |
mixed connective tissue disease |
|
| Synonyms |
connective tissue disease overlap syndrome mixed connective tissue disease mixed collagen vascular disease mixed collagen vascular disease (disorder) Connective tissue disease overlap syndrome (disorder) Mixed Connective Tissue Disease sharp syndrome MCTD |
|
| Definitions |
Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresivedrugsmay help manage the symptoms. A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen. |
|
| ID |
http://www.ebi.ac.uk/efo/EFO_0007374 |
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| closeMatch | ||
| database_cross_reference |
NANDO:1200278 SCTID:398049005 icd11.foundation:891652224 NCIT:C84892 MedDRA:10027754 UMLS:C0026272 NANDO:2200430 Orphanet:809 MeSH:D008947 MESH:D008947 DOID:3492 GARD:7051 NORD:1451 MONDO:0005854 |
|
| definition |
Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresivedrugsmay help manage the symptoms. A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen. |
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| exactMatch |
http://identifiers.org/mesh/D008947 http://purl.obolibrary.org/obo/Orphanet_809 http://identifiers.org/snomedct/398049005 http://purl.obolibrary.org/obo/DOID_3492 |
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| has_exact_synonym |
connective tissue disease overlap syndrome mixed connective tissue disease mixed collagen vascular disease mixed collagen vascular disease (disorder) Connective tissue disease overlap syndrome (disorder) Mixed Connective Tissue Disease sharp syndrome MCTD |
|
| id |
EFO:0007374 |
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| in_subset |
http://purl.obolibrary.org/obo/mondo/mondo-base#rare http://purl.obolibrary.org/obo/mondo/mondo-base#otar http://purl.obolibrary.org/obo/mondo/mondo-base#gard_rare http://purl.obolibrary.org/obo/mondo/mondo-base#orphanet_rare http://purl.obolibrary.org/obo/mondo/mondo-base#nord_rare http://purl.obolibrary.org/obo/mondo/mondo-base#ordo_disease |
|
| label |
mixed connective tissue disease |
|
| notation |
EFO:0007374 |
|
| preferred label |
mixed connective tissue disease |
|
| prefLabel |
mixed connective tissue disease |
|
| see also |
https://rarediseases.info.nih.gov/diseases/7051/mixed-connective-tissue-disease |
|
| term editor |
Sirarat Sarntivijai |
|
| subClassOf |
http://purl.obolibrary.org/obo/MONDO_0000589 |
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| excluded_subClassOf |