loading...| Preferred Name | mesothelial cell | |
| Synonyms |
mesotheliocyte |
|
| Definitions |
A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement. Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. |
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| ID |
http://purl.obolibrary.org/obo/CL_0000077 |
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| comment |
Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport. |
|
| database_cross_reference |
ZFA:0009040 FMA:66773 |
|
| definition |
A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement. |
|
| has_exact_synonym |
mesotheliocyte |
|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
|
| label |
mesothelial cell |
|
| preferred label |
mesothelial cell |
|
| prefixIRI |
CL:0000077 |
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| prefLabel |
mesothelial cell |
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| RO_0002175 | ||
| subClassOf |