Preferred Name

pravastatin
Synonyms

pravastatine

pravastatinum

pravastatina

pravastatin acid

(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

pravastatin

(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

Definitions

A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.

ID

http://purl.obolibrary.org/obo/CHEBI_63618

bearer of

http://purl.obolibrary.org/obo/CHEBI_35703

http://purl.obolibrary.org/obo/CHEBI_25212

http://purl.obolibrary.org/obo/CHEBI_78298

charge

0

formula

C23H36O7

has exact synonym

(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

has functional parent

http://purl.obolibrary.org/obo/CHEBI_63655

http://purl.obolibrary.org/obo/CHEBI_38655

has role

http://purl.obolibrary.org/obo/CHEBI_35703

http://purl.obolibrary.org/obo/CHEBI_25212

http://purl.obolibrary.org/obo/CHEBI_78298

hasAlternativeId

CHEBI:8360

hasOBONamespace

chebi_ontology

hasRelatedSynonym

pravastatine

pravastatinum

pravastatina

pravastatin acid

(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

pravastatin

id

CHEBI:63618

inchi

InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1

inchikey

TUZYXOIXSAXUGO-PZAWKZKUSA-N

inSubset

http://purl.obolibrary.org/obo/chebi#3_STAR

is conjugate acid of

http://purl.obolibrary.org/obo/CHEBI_63660

label

pravastatin

mass

424.52770

monoisotopicmass

424.24610

notation

CHEBI:63618

prefLabel

pravastatin

smiles

[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC

textual definition

A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.

xRef

Wikipedia:Pravastatin

Reaxys:4825538

PMID:25264019

PMID:21749370

HMDB:HMDB0005022

KEGG:C01844

LINCS:LSM-3347

PMID:21851379

DrugBank:DB00175

CAS:81093-37-0

Drug_Central:2239

KEGG:D08410

KNApSAcK:C00000565

subClassOf

http://purl.obolibrary.org/obo/CHEBI_36785

http://purl.obolibrary.org/obo/CHEBI_35868

http://purl.obolibrary.org/obo/CHEBI_33308

http://purl.obolibrary.org/obo/CHEBI_35681

http://purl.obolibrary.org/obo/CHEBI_61355

http://purl.obolibrary.org/obo/CHEBI_87633

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Delete Mapping To Ontology Source
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