The Drug Ontology

Last uploaded: December 20, 2024
Preferred Name

droperidol
Synonyms

1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one

1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one

droperidolum

1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone

1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone

droperidol

1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one

Definitions

An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.

ID

http://purl.obolibrary.org/obo/CHEBI_4717

alternative label

1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one

1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one

droperidolum

1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone

1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone

droperidol

1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one

charge

0

database_cross_reference

KEGG:D00308

Beilstein:579168

Wikipedia:Droperidol

LINCS:LSM-4193

DrugBank:DB00450

CAS:548-73-2

Drug_Central:966

Patent:US3161645

definition

An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.

formula

C22H22FN3O2

has characteristic

http://purl.obolibrary.org/obo/CHEBI_65190

http://purl.obolibrary.org/obo/CHEBI_50919

http://purl.obolibrary.org/obo/CHEBI_48561

http://purl.obolibrary.org/obo/CHEBI_60807

has role

http://purl.obolibrary.org/obo/CHEBI_65190

http://purl.obolibrary.org/obo/CHEBI_50919

http://purl.obolibrary.org/obo/CHEBI_48561

http://purl.obolibrary.org/obo/CHEBI_60807

has_alternative_id

CHEBI:252751

has_exact_synonym

1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one

has_obo_namespace

chebi_ontology

has_related_synonym

1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one

1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one

droperidolum

1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone

1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone

droperidol

has_RxCUI

3648

id

CHEBI:4717

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)

inchikey

RMEDXOLNCUSCGS-UHFFFAOYSA-N

label

droperidol

mass

379.42740

monoisotopicmass

379.16961

notation

CHEBI:4717

prefLabel

droperidol

smiles

Fc1ccc(cc1)C(=O)CCCN1CCC(=CC1)n1c2ccccc2[nH]c1=O

subClassOf

http://purl.obolibrary.org/obo/CHEBI_37143

http://purl.obolibrary.org/obo/CHEBI_76224

http://purl.obolibrary.org/obo/CHEBI_22715

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_4717 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4717 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4717 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4717 OBIB SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4717 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4717 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4717 BIOMODELS SAME_URI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004329 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006087 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0013136 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/001517 NDDF LOOM
http://purl.jp/bio/4/id/200906079863761591 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D004329 MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C458 BERO LOOM
http://www.drugbank.ca/drugs/DB00450 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4123 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/3648 RXNORM LOOM
https://go.drugbank.com/drugs/DB00450 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387146001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/N05AD08 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_4717 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_4717 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4717 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4717 OBIB LOOM
http://purl.obolibrary.org/obo/CHEBI_4717 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_4717 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_4717 BIOMODELS LOOM
http://purl.bioontology.org/ontology/VANDF/4019047 VANDF LOOM
http://www.case.edu/EpSO.owl#Droperidol MEPO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039227 PDQ LOOM
http://www.case.edu/EpilepsyOntology.owl#Droperidol EPSO LOOM
http://www.co-ode.org/ontologies/galen#Droperidol GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.103.393 RH-MESH LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass6221392e_d5d9_445c_868f_ed7581ea5b57 WWECA LOOM
http://stirdf.jst.go.jp/id/200907084169124484 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.522.352.343 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C458 NCIT LOOM
http://purl.obolibrary.org/obo/OMIT_0005585 OMIT LOOM
http://purl.bioontology.org/ontology/SNMI/C-63210 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/LP18863-8 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/x02LP RCD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017138 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147316 NDFRT LOOM
http://purl.obolibrary.org/obo/MESH_D004329 BERO LOOM