Preferred Name

glioblastoma

Synonyms

GBM (glioblastoma)

glioblastoma multiforme (disease)

GBM

grade IV astrocytic tumor

spongioblastoma multiforme

glioblastoma

primary glioblastoma multiforme

glioblastoma (disease)

glioblastoma multiforme

WHO grade IV glioma

grade IV astrocytoma

grade IV astrocytic neoplasm

gliosarcoma (histologic variant)

giant cell glioblastoma (histologic variant)

grade IV adult astrocytic tumor

Definitions

The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)

ID

http://purl.obolibrary.org/obo/MONDO_0018177

has characteristic

http://purl.obolibrary.org/obo/MONDO_0024494

has_exact_synonym

GBM (glioblastoma)

glioblastoma multiforme (disease)

GBM

grade IV astrocytic tumor

spongioblastoma multiforme

glioblastoma

primary glioblastoma multiforme

glioblastoma (disease)

glioblastoma multiforme

WHO grade IV glioma

grade IV astrocytoma

grade IV astrocytic neoplasm

has_narrow_synonym

grade IV adult astrocytic tumor

has_related_synonym

gliosarcoma (histologic variant)

giant cell glioblastoma (histologic variant)

IAO_0000233

https://github.com/monarch-initiative/mondo/issues/5798

IAO_0000589

glioblastoma (disease)

label

glioblastoma

prefixIRI

MONDO:0018177

prefLabel

glioblastoma

textual definition

The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)

subClassOf

http://purl.obolibrary.org/obo/MONDO_0016680

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