loading...| Preferred Name | glioblastoma | |
| Synonyms |
grade IV adult astrocytic tumor gliosarcoma (histologic variant) giant cell glioblastoma (histologic variant) GBM (glioblastoma) glioblastoma multiforme (disease) GBM grade IV astrocytic tumor spongioblastoma multiforme glioblastoma primary glioblastoma multiforme glioblastoma (disease) glioblastoma multiforme WHO grade IV glioma grade IV astrocytoma grade IV astrocytic neoplasm |
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| Definitions |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) |
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| ID |
http://purl.obolibrary.org/obo/MONDO_0018177 |
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| altLabel |
grade IV adult astrocytic tumor gliosarcoma (histologic variant) giant cell glioblastoma (histologic variant) GBM (glioblastoma) glioblastoma multiforme (disease) GBM grade IV astrocytic tumor spongioblastoma multiforme glioblastoma primary glioblastoma multiforme glioblastoma (disease) glioblastoma multiforme WHO grade IV glioma grade IV astrocytoma grade IV astrocytic neoplasm |
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| definition |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) |
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| has characteristic | ||
| has_exact_synonym |
GBM (glioblastoma) glioblastoma multiforme (disease) GBM grade IV astrocytic tumor spongioblastoma multiforme glioblastoma primary glioblastoma multiforme glioblastoma (disease) glioblastoma multiforme WHO grade IV glioma grade IV astrocytoma grade IV astrocytic neoplasm |
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| has_narrow_synonym |
grade IV adult astrocytic tumor |
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| has_related_synonym |
gliosarcoma (histologic variant) giant cell glioblastoma (histologic variant) |
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| IAO_0000233 | ||
| IAO_0000589 |
glioblastoma (disease) |
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| label |
glioblastoma |
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| prefixIRI |
MONDO:0018177 |
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| prefLabel |
glioblastoma |
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| textual definition |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO) |
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| subClassOf |