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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Preferred Name | cilastatin | |
| Synonyms |
(2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoic acid C16H26N2O5S |
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| ID |
http://purl.obolibrary.org/obo/dinto_DB01597 |
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| binds |
http://purl.obolibrary.org/obo/dinto_1975 |
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| CASRN |
82009-34-5
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| Definition |
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. [PubChem]
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| has pharmacological target | ||
| InChI |
InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
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| InChIKey |
InChIKey=DHSUYTOATWAVLW-WFVMDLQDSA-N
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| inhibits |
http://purl.obolibrary.org/obo/dinto_1975 |
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| label |
cilastatin
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|
| may interact with | ||
| prefixIRI |
obo2:dinto_DB01597
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|
| prefLabel |
cilastatin
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|
| SMILES |
N[C@@H](CSCCCC\C=C(/NC(=O)[C@H]1CC1(C)C)C(=O)O)C(=O)O
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|
| Synonym |
(2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoic acid C16H26N2O5S
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|
| xref |
PubChem Compound:6435415 PharmGKB:PA448998 PubChem Substance:46505611 Wikipedia:http://en.wikipedia.org/wiki/Cilastatin ChEBI:3697 ChemSpider:4444109 PDB:CIL
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| subClassOf |
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