The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

lisdexamfetamine
Synonyms

C15H25N3O

(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide

ID

http://purl.obolibrary.org/obo/dinto_DB01255

binds

http://purl.obolibrary.org/obo/dinto_3343

http://purl.obolibrary.org/obo/dinto_4020

blocks

http://purl.obolibrary.org/obo/dinto_4020

CASRN

608137-32-2

DBBrand

vyvanse

DBSynonym

nrp104

lisdexamfetamine dimesylate

Definition

Lisdexamfetamine (L-lysine-d-amphetamine) is a prodrug of the psychostimulant d-amphetamine coupled with the essential amino acid L-lysine. It was developed so that the amphetamine psychostimulant is released and activated more slowly as the prodrug molecule is hydrolyzed consequently cleaving off the amino acid-during the first pass through the intestines and/or the liver. Amphetamines target the trace amine-associated receptor 1 (TAAR1). Amphetamine is also believed to exert its effects by binding to the monoamine transporters (the dopamine transporter or DAT) and increasing extracellular levels of the biogenic amines dopamine, norepinephrine (noradrenaline) and serotonin.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_3343

InChI

InChI=1S/C15H25N3O/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19)/t12-,14-/m0/s1

InChIKey

InChIKey=VOBHXZCDAVEXEY-JSGCOSHPSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_3343

label

lisdexamfetamine

may interact with

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/dinto_DB00519

http://purl.obolibrary.org/obo/dinto_DB00427

http://purl.obolibrary.org/obo/dinto_DB00752

modulates

http://purl.obolibrary.org/obo/dinto_4020

prefixIRI

obo2:dinto_DB01255

prefLabel

lisdexamfetamine

SMILES

C[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](N)CCCCN

Synonym

C15H25N3O

(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide

xref

PubChem Compound:11597698

PharmGKB:PA164748975

National Drug Code Directory:59417-102-10

Wikipedia:http://en.wikipedia.org/wiki/Lisdexamfetamine

ChemSpider:9772458

RxList:http://www.rxlist.com/cgi/generic/vyvanse.htm

PubChem Substance:46505358

Drugs.com:http://www.drugs.com/cdi/lisdexamfetamine.html

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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