The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

hydrochlorothiazide
Synonyms

C7H8ClN3O4S2

6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

ID

http://purl.obolibrary.org/obo/dinto_DB00999

AHFScode

40:28.20

ATCCode

C03AA03

binds

http://purl.obolibrary.org/obo/dinto_0512

http://purl.obolibrary.org/obo/dinto_0757

http://purl.obolibrary.org/obo/dinto_3399

http://purl.obolibrary.org/obo/dinto_1621

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_2115

http://purl.obolibrary.org/obo/dinto_2357

http://purl.obolibrary.org/obo/dinto_3879

CASRN

58-93-5

DBBrand

thiaretic

panurin

hydrosaluric

dichlorosal

urodiazin

hidrochlortiazid

fluvin

timolide

diclotride

esidrex

disalunil

megadiuril

hydrozide

dichlotiazid

hydrodiuretic

caplaril

diu-melusin

hydril

ivaugan

nefrix

chlorzide

hydrothide

newtolide

dicyclotride

dichlorotride

neo-codema

neoflumen

idrotiazide

hydrodiuril

hydropres

apresazide

maschitt

hypothiazide

thiuretic

hidroronol

drenol

bremil

direma

aquarills

jen-diril

dichlotride

hypothiazid

hydro-aquil

cidrex

microzide

thlaretic

hidril

vetidrex

ro-hydrazide

servithiazid

hidrotiazida

chlorosulthiadil

aquarius

DBSynonym

dihydrochlorurite

dihydroxychlorothiazidum

dihydrochlorurit

hcz

dihydrochlorothiazide

hctz

dihydrochlorothiazid

dihydrochlorothiazidum

hydrochlorothiazid

hydrochlorthiazide

Definition

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [PubChem]

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001520

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000825

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000913

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0001064

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0001051

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0001195

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0001339

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001378

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0000287

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000851

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000643

http://purl.obolibrary.org/obo/OAE_0001106

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0000752

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000468

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0001465

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000347

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0757

InChI

InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChIKey

InChIKey=JZUFKLXOESDKRF-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_0512

http://purl.obolibrary.org/obo/dinto_0757

http://purl.obolibrary.org/obo/dinto_3399

http://purl.obolibrary.org/obo/dinto_1621

http://purl.obolibrary.org/obo/dinto_0520

http://purl.obolibrary.org/obo/dinto_2115

http://purl.obolibrary.org/obo/dinto_2357

label

hydrochlorothiazide

may interact with

http://purl.obolibrary.org/obo/dinto_DB01551

http://purl.obolibrary.org/obo/dinto_DB00469

http://purl.obolibrary.org/obo/dinto_DB00519

http://purl.obolibrary.org/obo/CHEBI_4551

http://purl.obolibrary.org/obo/CHEBI_31468

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_50861

http://purl.obolibrary.org/obo/dinto_DB01396

http://purl.obolibrary.org/obo/CHEBI_4495

http://purl.obolibrary.org/obo/dinto_DB00046

http://purl.obolibrary.org/obo/CHEBI_68575

http://purl.obolibrary.org/obo/CHEBI_4681

prefixIRI

obo2:dinto_DB00999

prefLabel

hydrochlorothiazide

related with

http://purl.obolibrary.org/obo/dinto_3879

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1

Synonym

C7H8ClN3O4S2

6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

xref

PharmGKB:PA449899

Drugs Product Database (DPD):2247386

BindingDB:13076

National Drug Code Directory:0378-3603-01

Wikipedia:http://en.wikipedia.org/wiki/Hydrochlorothiazide

RxList:http://www.rxlist.com/cgi/generic/hctz.htm

Drugs.com:http://www.drugs.com/hctz.html

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.bioontology.org/ontology/NDFRT/N0000145995 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00999 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.135.261.476 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0020261 HFO LOOM
http://purl.obolibrary.org/obo/OMIT_0007993 OMIT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017425 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020261 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.174.261.476 RH-MESH LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Hydrochlorothiazide SEPON LOOM
http://purl.bioontology.org/ontology/ATC/C03AA03 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D006852 BERO LOOM
http://www.co-ode.org/ontologies/galen#Hydrochlorothiazide GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6347 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.655.500.261.476 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/b26.. RCD LOOM
http://www.ifomis.org/acgt/1.0#Hydrochlorothiazide ACGT-MO LOOM
rgo:24939 GAMUTS LOOM
http://purl.bioontology.org/ontology/MESH/D006852 MESH LOOM
http://stirdf.jst.go.jp/id/200907079016032480 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5778 OBA LOOM
http://purl.bioontology.org/ontology/SNMI/C-72260 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387525002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/5487 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29098 NCIT LOOM
http://purl.obolibrary.org/obo/XCO_0000899 XCO LOOM
http://purl.bioontology.org/ontology/VANDF/4017615 VANDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145995 OCVDAE LOOM
http://purl.obolibrary.org/obo/NCIT_C29098 BERO LOOM
http://purl.bioontology.org/ontology/LNC/LP16160-1 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060558 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/002294 NDDF LOOM
http://purl.jp/bio/4/id/200906026825052777 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006852 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00999 MDM LOOM