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The Drug-Drug Interactions Ontology
| Preferred Name | disulfiram | |
| Synonyms |
N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide C10H20N2S4 |
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| ID |
http://purl.obolibrary.org/obo/dinto_DB00822 |
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| ATCCode |
N07BB01 P03AA04
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| binds |
http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2840 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_2685 |
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| CASRN |
97-77-8
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| DBBrand |
ekagom tetds refusal cronetal ethyl thiram ro-sulfiram tts x anti-ethyl ekagom dtet super rodiatox ethyl thiurad thireranide antikol stopethyl antetil abstinil anticol soxinol tet accel tet-r etabus antaetil perkait tetd tetraetil abstensil ethyl tuex ancazide et antetan alk-aubs tetidis alcophobin nocceler tet antivitium teturam abstinyl tts accel tet antadix perkacit tetd bonibal nocceler tet-g antaethan thiocid akrochem tetd disulfram ethyldithiourame anthethyl tetradin stopetyl thiophos antietil antaenyl ethyl tuads rodform sanceler tet tetradine antietanol ethyldithiurame contralin esperal dicupral antabus aversan espenal nocbin averzan sanceler tet-g ekagom teds ethyl tuads tenutex teturamin stopaethyl anteyl antaethyl noxal antalcol exhoran tenurid krotenal hoca antiaethan contrapot disetil tillram ekaland tetd antabuse exhorran ephorran stopety tiuram disulfan ethyl thiudad gababentin etyl tuex antethyl
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| DBSynonym |
ttd tatd tetraethylthiram disulphide tetraethylthiuram disulphide disulphuram tetraethylthiuram sulfide tetd dupon 4472 tetraethylthiuran disulfide tetraethylthiuram disulfide usaf b-33 tetraethylthiram disulfide disulfuram dupont fungicide 4472 tetraethylthiuram tetraethylthioperoxydicarbonic diamide
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| Definition |
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase. [PubChem]
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|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000086 |
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| has pharmacological target | ||
| InChI |
InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
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|
| InChIKey |
InChIKey=AUZONCFQVSMFAP-UHFFFAOYSA-N
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|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2840 |
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| is metabolised by | ||
| is substrate of | ||
| label |
disulfiram
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| may interact with |
http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_3655 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_4728 http://purl.obolibrary.org/obo/CHEBI_6909 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_27958 http://purl.obolibrary.org/obo/dinto_DB00347 http://purl.obolibrary.org/obo/dinto_DB01320 |
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| prefixIRI |
obo2:dinto_DB00822
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|
| prefLabel |
disulfiram
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|
| SMILES |
CCN(CC)C(=S)SSC(=S)N(CC)CC
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|
| Synonym |
N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide C10H20N2S4
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|
| xref |
ChemSpider:3005 National Drug Code Directory:49884-153-01 ChEBI:4659 Wikipedia:http://en.wikipedia.org/wiki/Disulfiram RxList:http://www.rxlist.com/cgi/generic/disulfiram.htm PubChem Substance:46506008 Drugs.com:http://www.drugs.com/cdi/disulfiram.html PharmGKB:PA449376 Drugs Product Database (DPD):2534 PubChem Compound:3117
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| subClassOf |
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